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DAK2 dihydroxyacetone kinase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850491, updated on 17-May-2024

Summary

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Gene symbol
DAK2
Gene description
dihydroxyacetone kinase
Primary source
FungiDB:YFL053W
Locus tag
YFL053W
See related
SGD:S000001841; AllianceGenome:SGD:S000001841
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables glycerone kinase activity. Involved in cellular response to toxic substance and glycerol to glycerone phosphate metabolic process. Predicted to be active in cytosol. Orthologous to human TKFC (triokinase and FMN cyclase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (23423..25198)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Agp3p Neighboring gene Aqy3p Neighboring gene DNA-binding domain containing protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dihydroxyacetone-induced death is accompanied by advanced glycation endproduct formation in selected proteins of Saccharomyces cerevisiae and Caenorhabditis elegans. Molin M, et al. Proteomics, 2007 Oct. PMID 17890650
  2. Dihydroxyacetone detoxification in Saccharomyces cerevisiae involves formaldehyde dissimilation. Molin M, et al. Mol Microbiol, 2006 May. PMID 16677304
  3. Fragmentation of dihydroxyacetone kinase 1 from Saccharomyces cerevisiae indicates a two-domain structure. Molin M, et al. Proteomics, 2003 May. PMID 12748953
  4. Cloning, sequencing and characterization of a gene encoding dihydroxyacetone kinase from Zygosaccharomyces rouxii NRRL2547. Wang ZX, et al. Yeast, 2002 Dec. PMID 12478592
  5. Dihydroxyacetone kinases in Saccharomyces cerevisiae are involved in detoxification of dihydroxyacetone. Molin M, et al. J Biol Chem, 2003 Jan 17. PMID 12401799

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables glycerone kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerone kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerone kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables glycerone kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables triokinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anaerobic glycerol catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol to glycerone phosphate metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dihydroxyacetone kinase
NP_116602.1
  • Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    23423..25198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179914.1 → NP_116602.1  TPA: dihydroxyacetone kinase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116602.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTH7, P43550
    UniProtKB/TrEMBL
    A0A8H8UL33, C7GY59, N1P4R0
    Conserved Domains (1) summary
    TIGR02361
    Location:4 → 586
    dak_ATP; dihydroxyacetone kinase, ATP-dependent
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43550.1

Gene LinkOut

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