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SEC53 phosphomannomutase SEC53 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850499, updated on 5-May-2024

Summary

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Gene symbol
SEC53
Gene description
phosphomannomutase SEC53
Primary source
SGD:S000001849
Locus tag
YFL045C
See related
AllianceGenome:SGD:S000001849
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ALG4
Summary
Enables phosphomannomutase activity. Predicted to be involved in mannose metabolic process and protein N-linked glycosylation. Located in cytosol. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation Ia. Orthologous to several human genes including PMM2 (phosphomannomutase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (43628..44392, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein RGD2 Neighboring gene Fmp32p Neighboring gene ubiquitin-specific protease OTU1 Neighboring gene Lam5p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast Models of Phosphomannomutase 2 Deficiency, a Congenital Disorder of Glycosylation. Lao JP, et al. G3 (Bethesda), 2019 Feb 7. PMID 30530630, Free PMC Article
  2. Genes required for completion of import of proteins into the endoplasmic reticulum in yeast. Ferro-Novick S, et al. J Cell Biol, 1984 Jan. PMID 6368572, Free PMC Article
  3. Characterization of a gene product (Sec53p) required for protein assembly in the yeast endoplasmic reticulum. Bernstein M, et al. J Cell Biol, 1985 Dec. PMID 3905826, Free PMC Article
  4. Sec53, a protein required for an early step in secretory protein processing and transport in yeast, interacts with the cytoplasmic surface of the endoplasmic reticulum. Ruohola H, et al. Proc Natl Acad Sci U S A, 1987 Dec. PMID 3317409, Free PMC Article
  5. Product of SEC53 is required for folding and glycosylation of secretory proteins in the lumen of the yeast endoplasmic reticulum. Feldman RI, et al. J Biol Chem, 1987 Jul 5. PMID 3298255

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphomannomutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphomannomutase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphomannomutase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GDP-mannose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in mannose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphomannomutase SEC53
NP_116609.1
  • Phosphomannomutase; involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen; human homolog PMM2 complements yeast mutants

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    43628..44392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179922.1 → NP_116609.1  TPA: phosphomannomutase SEC53 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116609.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTI5, P07283, Q70D76, Q70D77
    UniProtKB/TrEMBL
    A0A6A5PZC5, A7A1Z4, B3LUG6, B5VHY2, C7GY69, C8Z7N7, G2WD96, N1P4H2
    Conserved Domains (1) summary
    pfam03332
    Location:35 → 254
    PMM; Eukaryotic phosphomannomutase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07283.1

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