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AGX1 alanine--glyoxylate transaminase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850514, updated on 17-May-2024

Summary

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Gene symbol
AGX1
Gene description
alanine--glyoxylate transaminase
Primary source
FungiDB:YFL030W
Locus tag
YFL030W
See related
SGD:S000001864; AllianceGenome:SGD:S000001864
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables alanine-glyoxylate transaminase activity. Involved in glycine biosynthetic process, by transamination of glyoxylate. Located in cytosol and mitochondrion. Used to study primary hyperoxaluria. Human ortholog(s) of this gene implicated in primary hyperoxaluria type 1. Orthologous to human AGXT (alanine--glyoxylate and serine--pyruvate aminotransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (76831..77988)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene protein kinase RIM15 Neighboring gene transcription factor HAC1 Neighboring gene cyclin-dependent protein kinase-activating kinase CAK1 Neighboring gene putative ATP-binding cassette family ATPase CAF16

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure and confirmation of the alanine:glyoxylate aminotransferase activity of the YFL030w yeast protein. Meyer P, et al. Biochimie, 2005 Dec. PMID 16226833
  2. Characteristics of alanine: glyoxylate aminotransferase from Saccharomyces cerevisiae, a regulatory enzyme in the glyoxylate pathway of glycine and serine biosynthesis from tricarboxylic acid-cycle intermediates. Takada Y, et al. Biochem J, 1985 Oct 1. PMID 3933486, Free PMC Article
  3. In vivo and in vitro examination of stability of primary hyperoxaluria-associated human alanine:glyoxylate aminotransferase. Hopper ED, et al. J Biol Chem, 2008 Nov 7. PMID 18782763, Free PMC Article
  4. Alanine : glyoxylate aminotransferase of Saccharomyces cerevisiae-encoding gene AGX1 and metabolic significance. Schlösser T, et al. Yeast, 2004 Jan 15. PMID 14745783
  5. Identifying and assessing the impact of wine acid-related genes in yeast. Chidi BS, et al. Curr Genet, 2016 Feb. PMID 26040556

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alanine-glyoxylate transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alanine-glyoxylate transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alanine-glyoxylate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables alanine-glyoxylate transaminase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables serine-pyruvate transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycine biosynthetic process, by transamination of glyoxylate IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine biosynthetic process, by transamination of glyoxylate IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in mitochondrion HDA PubMed 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
alanine--glyoxylate transaminase
NP_116623.1
  • Alanine:glyoxylate aminotransferase (AGT); catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; similar to mammalian and plant alanine:glyoxylate aminotransferases; human homolog AGXT complements yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    76831..77988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179936.1 → NP_116623.1  TPA: alanine--glyoxylate transaminase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116623.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTK0, P43567
    UniProtKB/TrEMBL
    A0A6A5PXN3, A7A209, B3LUI1, C7GY81, C8Z7Q3, G2WDB1, N1PA19
    Conserved Domains (1) summary
    cd06451
    Location:7 → 378
    AGAT_like; Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43567.1

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