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FRS2 phenylalanine--tRNA ligase subunit alpha [ Saccharomyces cerevisiae S288C ]

Gene ID: 850522, updated on 17-May-2024

Summary

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Gene symbol
FRS2
Gene description
phenylalanine--tRNA ligase subunit alpha
Primary source
FungiDB:YFL022C
Locus tag
YFL022C
See related
SGD:S000001872; AllianceGenome:SGD:S000001872
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables aminoacyl-tRNA editing activity. Contributes to phenylalanine-tRNA ligase activity. Involved in phenylalanyl-tRNA aminoacylation. Located in cytoplasm. Part of phenylalanine-tRNA ligase complex. Orthologous to human FARSA (phenylalanyl-tRNA synthetase subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (93499..95010, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Epl1p Neighboring gene Bud27p Neighboring gene Gat1p Neighboring gene seripauperin PAU5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple Quality Control Pathways Limit Non-protein Amino Acid Use by Yeast Cytoplasmic Phenylalanyl-tRNA Synthetase. Moghal A, et al. J Biol Chem, 2016 Jul 22. PMID 27226603, Free PMC Article
  2. Tailoring the substrate specificity of yeast phenylalanyl-tRNA synthetase toward a phenylalanine analog using multiple-site-specific incorporation. Kwon I, et al. ACS Synth Biol, 2015 May 15. PMID 25268049
  3. Design of a bacterial host for site-specific incorporation of p-bromophenylalanine into recombinant proteins. Kwon I, et al. J Am Chem Soc, 2006 Sep 13. PMID 16953616
  4. Expansion of the genetic code: site-directed p-fluoro-phenylalanine incorporation in Escherichia coli. Furter R. Protein Sci, 1998 Feb. PMID 9521119, Free PMC Article
  5. Conservation in evolution for a small monomeric phenylalanyl-tRNA synthetase of the tRNA(Phe) recognition nucleotides and initial aminoacylation site. Aphasizhev R, et al. Biochemistry, 1996 Jan 9. PMID 8555164

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA editing activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity, acting on a tRNA IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phenylalanine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
Inferred from Electronic Annotation
more info
  
involved_in phenylalanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phenylalanyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phenylalanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of phenylalanine-tRNA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phenylalanine-tRNA ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phenylalanine--tRNA ligase subunit alpha
NP_116631.1
  • Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    93499..95010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179944.2 → NP_116631.1  TPA: phenylalanine--tRNA ligase subunit alpha [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116631.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTK8, P15625
    UniProtKB/TrEMBL
    A0A7I9ET35, B3LUI8, C8Z7R1, G2WDB9, N1P357
    Conserved Domains (1) summary
    PTZ00326
    Location:1 → 486
    PTZ00326; phenylalanyl-tRNA synthetase alpha chain; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15625.3

Gene LinkOut

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