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HIS2 histidinol-phosphatase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850581, updated on 11-Apr-2024

Summary

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Gene symbol
HIS2
Gene description
histidinol-phosphatase
Primary source
SGD:S000001921
Locus tag
YFR025C
See related
AllianceGenome:SGD:S000001921
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables histidinol-phosphatase activity. Involved in histidine biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (203743..204750, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Pes4p Neighboring gene Lsb3p Neighboring gene tRNA-Ala Neighboring gene Uli1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic analysis of a gene required for the expression of allele-specific missense suppression in Saccharomyces cerevisiae. Gorman JA, et al. Genetics, 1971 Mar. PMID 4329443, Free PMC Article
  2. The separation and partial characterization of L-histidinol phosphatase and an alkaline phosphatase of Saccharomyces cerevisiae. Gorman JA, et al. J Biol Chem, 1969 Mar 25. PMID 4304232
  3. GENE-ENZYME RELATIONS IN HISTIDINE BIOSYNTHESIS IN YEAST. FINK GR. Science, 1964 Oct 23. PMID 14190241
  4. Toxicity of copper, cobalt, and nickel salts is dependent on histidine metabolism in the yeast Saccharomyces cerevisiae. Pearce DA, et al. J Bacteriol, 1999 Aug. PMID 10438744, Free PMC Article
  5. αβ'-NAC cooperates with Sam37 to mediate early stages of mitochondrial protein import. Ponce-Rojas JC, et al. FEBS J, 2017 Mar. PMID 28109174

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables histidinol-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histidinol-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables histidinol-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in histidine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in histidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in histidine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 

General protein information

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Preferred Names
histidinol-phosphatase
NP_116681.1
  • Histidinolphosphatase; catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    203743..204750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179990.1 → NP_116681.1  TPA: histidinol-phosphatase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116681.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTQ5, P38635
    UniProtKB/TrEMBL
    A0A8H8ULA7, B3LUN4, B5VI52, C8Z7W0
    Conserved Domains (1) summary
    TIGR01856
    Location:2 → 292
    hisJ_fam; histidinol phosphate phosphatase, HisJ family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38635.2

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