U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HXK1 hexokinase 1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850614, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Gene symbol
HXK1
Gene description
hexokinase 1
Primary source
SGD:S000001949
Locus tag
YFR053C
See related
AllianceGenome:SGD:S000001949
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables hexokinase activity. Involved in glycolytic process; hexose metabolic process; and hexose transmembrane transport. Located in mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 4G; anemia (multiple); artery disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to several human genes including GCK (glucokinase). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (253592..255049, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene coatomer subunit delta Neighboring gene proteasome regulatory particle lid subunit RPN12 Neighboring gene uncharacterized protein Neighboring gene cysteine-S-conjugate beta-lyase IRC7

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Crystal structure of yeast hexokinase PI in complex with glucose: A classical "induced fit" example revised. Kuser P, et al. Proteins, 2008 Aug. PMID 18260108
  2. Kinetic and proteomic analyses of S-nitrosoglutathione-treated hexokinase A: consequences for cancer energy metabolism. Miller S, et al. Amino Acids, 2007. PMID 17051422
  3. Nuclear pore association confers optimal expression levels for an inducible yeast gene. Taddei A, et al. Nature, 2006 Jun 8. PMID 16760983
  4. Glucose sensing based on the intrinsic fluorescence of sol-gel immobilized yeast hexokinase. Hussain F, et al. Anal Biochem, 2005 Apr 1. PMID 15766720
  5. Time-resolved fluorescence of tryptophans in yeast hexokinase-PI: effect of subunit dimerization and ligand binding. Maity H, et al. J Photochem Photobiol B, 2000 Mar. PMID 10877063

See all (157) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proteomic consequences of TDA1 deficiency in Saccharomyces cerevisiae: Protein kinase Tda1 is essential for Hxk1 and Hxk2 serine 15 phosphorylation.
    Title: Proteomic consequences of TDA1 deficiency in Saccharomyces cerevisiae: Protein kinase Tda1 is essential for Hxk1 and Hxk2 serine 15 phosphorylation.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables fructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucose binding IEA
Inferred from Electronic Annotation
more info
  
enables hexokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hexokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexokinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in carbohydrate derivative metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose import across plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in fructose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in generation of precursor metabolites and energy IEA
Inferred from Electronic Annotation
more info
  
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose import IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
involved_in hexose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular glucose homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in mannose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mannose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in organophosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
hexokinase 1
NP_116711.3
  • Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    253592..255049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180018.3 → NP_116711.3  TPA: hexokinase 1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116711.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTT6, P04806
    UniProtKB/TrEMBL
    A0A8H8ULD6, C7GYF6, G4XS65, N1P4S9
    Conserved Domains (1) summary
    COG5026
    Location:6 → 477
    COG5026; Hexokinase [Carbohydrate transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04806.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous