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YEH1 sterol esterase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850648, updated on 13-Apr-2024

Summary

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Gene symbol
YEH1
Gene description
sterol esterase
Primary source
SGD:S000003935
Locus tag
YLL012W
See related
AllianceGenome:SGD:S000003935
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables sterol esterase activity. Involved in sterol metabolic process. Located in lipid droplet. Is integral component of membrane. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; cholesterol ester storage disease; and lysosomal and lipase deficiency. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPK (lipase family member K). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (125534..127255)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Emc6p Neighboring gene mRNA-binding protein PUF3 Neighboring gene rRNA-processing protein SOF1 Neighboring gene phosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of sterol-ester hydrolase in Saccharomyces cerevisiae. Taketani S, et al. Biochim Biophys Acta, 1978 Jul 7. PMID 28772
  2. Mobilization of steryl esters from lipid particles of the yeast Saccharomyces cerevisiae. Wagner A, et al. Biochim Biophys Acta, 2009 Feb. PMID 19111628
  3. The Saccharomyces cerevisiae YLL012/YEH1, YLR020/YEH2, and TGL1 genes encode a novel family of membrane-anchored lipases that are required for steryl ester hydrolysis. Köffel R, et al. Mol Cell Biol, 2005 Mar. PMID 15713625, Free PMC Article
  4. Regulatory link between steryl ester formation and hydrolysis in the yeast Saccharomyces cerevisiae. Ploier B, et al. Biochim Biophys Acta, 2015 Jul. PMID 25720564
  5. Yeh1 constitutes the major steryl ester hydrolase under heme-deficient conditions in Saccharomyces cerevisiae. Köffel R, et al. Eukaryot Cell, 2006 Jul. PMID 16835446, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study demonstrates a strong regulation of the two lipid droplet associated steryl ester hydrolases Tgl1p and Yeh1p due to the presence/absence of their host organelle.
    Title: The impact of nonpolar lipids on the regulation of the steryl ester hydrolases Tgl1p and Yeh1p in the yeast Saccharomyces cerevisiae.
  2. Yeh1 is the sole active steryl ester hydrolase under heme-deficient conditions, indicating that Yeh1 is activated whereas Yeh2 and Tgl1 are inactivated by the lack of heme.
    Title: Yeh1 constitutes the major steryl ester hydrolase under heme-deficient conditions in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables sterol esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sterol esterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sterol esterase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sterol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in lipid droplet HDA PubMed 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sterol esterase
NP_013089.1
  • Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes; YEH1 has a paralog, YEH2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    125534..127255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181832.1 → NP_013089.1  TPA: sterol esterase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013089.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXZ0, Q07804
    UniProtKB/TrEMBL
    A0A8H4F8H9, G2WII3, N1P0A1
    Conserved Domains (1) summary
    PLN02872
    Location:169 → 326
    PLN02872; triacylglycerol lipase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07804.1

Gene LinkOut

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