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YBT1 bile acid-transporting ATPase YBT1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850678, updated on 4-Jan-2025

Summary

Official Symbol
YBT1
Official Full Name
bile acid-transporting ATPase YBT1
Primary source
SGD:S000003971
Locus tag
YLL048C
See related
AllianceGenome:SGD:S000003971; FungiDB:YLL048C; VEuPathDB:YLL048C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
BAT1
Summary
Enables ATPase-coupled monocarboxylic acid transmembrane transporter activity. Involved in monocarboxylic acid transport. Located in fungal-type vacuole membrane and membrane raft. Human ortholog(s) of this gene implicated in several diseases, including dilated cardiomyopathy (multiple); familial atrial fibrillation; glucose metabolism disease (multiple); hypertrichotic osteochondrodysplasia Cantu type; and intellectual disability and myopathy syndrome. Orthologous to human ABCC10 (ATP binding cassette subfamily C member 10); ABCC8 (ATP binding cassette subfamily C member 8); and ABCC9 (ATP binding cassette subfamily C member 9). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See YBT1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (41280..46265, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene cofilin Neighboring gene Ldb18p Neighboring gene Rnp1p Neighboring gene ribosomal 60S subunit protein L8B

Bibliography

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by SGD

Process Evidence Code Pubs
involved_in calcium ion transport  
involved_in monocarboxylic acid transport PubMed 
involved_in transmembrane transport  
involved_in transmembrane transport  
Component Evidence Code Pubs
located_in endoplasmic reticulum PubMed 
located_in fungal-type vacuole PubMed 
is_active_in fungal-type vacuole membrane  
located_in fungal-type vacuole membrane PubMed 
located_in membrane  
located_in membrane raft PubMed 
located_in vacuolar membrane  
located_in vacuole  

General protein information

Preferred Names
bile acid-transporting ATPase YBT1
NP_013052.1
  • Transporter of ATP-binding cassette (ABC) family; targeted to vacuole via AP-3 pathway; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    41280..46265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181868.1NP_013052.1  TPA: bile acid-transporting ATPase YBT1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013052.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXW0, P32386, Q07882
    UniProtKB/TrEMBL
    C7GNE7
    Conserved Domains (1) summary
    TIGR00957
    Location:3531639
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
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