ERG3 C-5 sterol desaturase [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: ERG3
Gene description: C-5 sterol desaturase
Primary source: SGD:S000004046
Locus tag: YLR056W
See related: AllianceGenome:SGD:S000004046
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PSO6; SYR1
Summary: Enables C-5 sterol desaturase activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum lumen. Orthologous to human SC5D (sterol-C5-desaturase). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables C-5 sterol desaturase activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-5 sterol desaturase activity	IDA Inferred from Direct Assay more info	PubMed
enables C-5 sterol desaturase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables delta7-sterol 5(6)-desaturase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ergosterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in sterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sterol biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	NAS Non-traceable Author Statement more info	PubMed
located_in endoplasmic reticulum lumen	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_013157.1

C-5 sterol desaturase; glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; transcriptionally down-regulated when ergosterol is in excess; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of HRD ubiquitin ligase; mutation is functionally complemented by human SC5D

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The following sections contain reference sequences that belong to a specific genome build. Explain