U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

FRS1 phenylalanine--tRNA ligase subunit beta [ Saccharomyces cerevisiae S288C ]

Gene ID: 850749, updated on 17-May-2024

Summary

Go to the top of the page Help
Gene symbol
FRS1
Gene description
phenylalanine--tRNA ligase subunit beta
Primary source
FungiDB:YLR060W
Locus tag
YLR060W
See related
SGD:S000004050; AllianceGenome:SGD:S000004050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to phenylalanine-tRNA ligase activity. Involved in phenylalanyl-tRNA aminoacylation. Located in cytoplasm. Part of phenylalanine-tRNA ligase complex. Orthologous to human FARSB (phenylalanyl-tRNA synthetase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (260979..262766)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene glycine hydroxymethyltransferase SHM2 Neighboring gene Rex2p Neighboring gene ribosomal 60S subunit protein L22A Neighboring gene 25S rRNA (uracil2843-N3)-methyltransferase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Editing of misaminoacylated tRNA controls the sensitivity of amino acid stress responses in Saccharomyces cerevisiae. Mohler K, et al. Nucleic Acids Res, 2017 Apr 20. PMID 28168297, Free PMC Article
  2. Phenylalanyl-tRNA synthetase contains a dispensable RNA-binding domain that contributes to the editing of noncognate aminoacyl-tRNA. Roy H, et al. Biochemistry, 2006 Aug 1. PMID 16866361
  3. Identification of the major tRNA(Phe) binding domain in the tetrameric structure of cytoplasmic phenylalanyl-tRNA synthetase from baker's yeast. Fasiolo F, et al. FEBS Lett, 1989 Jan 2. PMID 2644133
  4. Multiple Quality Control Pathways Limit Non-protein Amino Acid Use by Yeast Cytoplasmic Phenylalanyl-tRNA Synthetase. Moghal A, et al. J Biol Chem, 2016 Jul 22. PMID 27226603, Free PMC Article
  5. Tailoring the substrate specificity of yeast phenylalanyl-tRNA synthetase toward a phenylalanine analog using multiple-site-specific incorporation. Kwon I, et al. ACS Synth Biol, 2015 May 15. PMID 25268049

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to phenylalanine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phenylalanine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in phenylalanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phenylalanyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phenylalanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of phenylalanine-tRNA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phenylalanine-tRNA ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
phenylalanine--tRNA ligase subunit beta
NP_013161.1
  • Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    260979..262766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181947.1 → NP_013161.1  TPA: phenylalanine--tRNA ligase subunit beta [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013161.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY62, E9P8X0, P15624
    UniProtKB/TrEMBL
    A0A6L1BCX5, C8ZD32, G2WIQ3, N1NZH0
    Conserved Domains (1) summary
    TIGR00471
    Location:1 → 595
    pheT_arch; phenylalanyl-tRNA synthetase, beta subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15624.3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous