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GAL2 galactose permease GAL2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850770, updated on 13-Apr-2024

Summary

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Gene symbol
GAL2
Gene description
galactose permease GAL2
Primary source
SGD:S000004071
Locus tag
YLR081W
See related
AllianceGenome:SGD:S000004071
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables galactose transmembrane transporter activity and glucose transmembrane transporter activity. Involved in galactose metabolic process and galactose transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (290212..291936)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1 Neighboring gene Emp46p Neighboring gene Srl2p Neighboring gene Emp70p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a glucose-insensitive variant of Gal2 from Saccharomyces cerevisiae exhibiting a high pentose transport capacity. Rojas SAT, et al. Sci Rep, 2021 Dec 22. PMID 34937866, Free PMC Article
  2. l-Arabinose triggers its own uptake via induction of the arabinose-specific Gal2p transporter in an industrial Saccharomyces cerevisiae strain. Oehling V, et al. Biotechnol Biofuels, 2018. PMID 30159031, Free PMC Article
  3. Improved xylose uptake in Saccharomyces cerevisiae due to directed evolution of galactose permease Gal2 for sugar co-consumption. Reznicek O, et al. J Appl Microbiol, 2015 Jul. PMID 25882005
  4. Metabolome, transcriptome and metabolic flux analysis of arabinose fermentation by engineered Saccharomyces cerevisiae. Wisselink HW, et al. Metab Eng, 2010 Nov. PMID 20816840
  5. Interaction between the critical aromatic amino acid residues Tyr(352) and Phe(504) in the yeast Gal2 transporter. Kasahara T, et al. FEBS Lett, 2000 Apr 7. PMID 10760522

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of a glucose-insensitive variant of Gal2 from Saccharomyces cerevisiae exhibiting a high pentose transport capacity.
    Title: Identification of a glucose-insensitive variant of Gal2 from Saccharomyces cerevisiae exhibiting a high pentose transport capacity.
  2. In this study, we show that the other components of SCF(Grr1), including Skp1, Rbx1p, and the ubiquitin-conjugating enzyme Cdc34, are also necessary for glucose-induced Gal2p degradation.
    Title: The ubiquitin ligase SCF(Grr1) is required for Gal2p degradation in the yeast Saccharomyces cerevisiae.
  3. The roles of GAL1 and GAL2 in the activation of the galactose metabolism network of S. cerevisiae are reported.
    Title: The regulatory roles of the galactose permease and kinase in the induction response of the GAL network in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables carbohydrate:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactose transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glucose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucose transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in galactose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in galactose transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in organic substance transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
galactose permease GAL2
NP_013182.1
  • Galactose permease; required for utilization of galactose; also able to transport glucose

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    290212..291936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181968.1 → NP_013182.1  TPA: galactose permease GAL2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013182.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY81, P13181, Q12521
    UniProtKB/TrEMBL
    A0A8H4BZD9
    Conserved Domains (2) summary
    cd06174
    Location:75 → 518
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:74 → 534
    Sugar_tr; Sugar (and other) transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13181.3

Gene LinkOut

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