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COQ9 ubiquinone biosynthesis protein COQ9 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850898, updated on 17-May-2024

Summary

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Gene symbol
COQ9
Gene description
ubiquinone biosynthesis protein COQ9
Primary source
FungiDB:YLR201C
Locus tag
YLR201C
See related
SGD:S000004191; AllianceGenome:SGD:S000004191
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable lipid binding activity. Involved in ubiquinone-6 biosynthetic process. Located in mitochondrial inner membrane. Used to study coenzyme Q10 deficiency disease. Human ortholog(s) of this gene implicated in coenzyme Q10 deficiency disease and primary coenzyme Q10 deficiency 5. Orthologous to human COQ9 (coenzyme Q9). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (549511..550293, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Pba1p Neighboring gene tubulin-binding prefolding complex subunit YKE2 Neighboring gene Mss51p Neighboring gene mitochondrial 37S ribosomal protein QRI5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast Coq9 controls deamination of coenzyme Q intermediates that derive from para-aminobenzoic acid. He CH, et al. Biochim Biophys Acta, 2015 Sep. PMID 26008578, Free PMC Article
  2. Human COQ10A and COQ10B are distinct lipid-binding START domain proteins required for coenzyme Q function. Tsui HS, et al. J Lipid Res, 2019 Jul. PMID 31048406, Free PMC Article
  3. An Isoprene Lipid-Binding Protein Promotes Eukaryotic Coenzyme Q Biosynthesis. Lohman DC, et al. Mol Cell, 2019 Feb 21. PMID 30661980, Free PMC Article
  4. Coq6 is responsible for the C4-deamination reaction in coenzyme Q biosynthesis in Saccharomyces cerevisiae. Ozeir M, et al. J Biol Chem, 2015 Oct 2. PMID 26260787, Free PMC Article
  5. A nonsense mutation in COQ9 causes autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency: a potentially treatable form of mitochondrial disease. Duncan AJ, et al. Am J Hum Genet, 2009 May. PMID 19375058, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identify a molecular interface between COQ9 and the hydroxylase COQ7, and suggest a model whereby COQ9 presents intermediates directly to CoQ enzymes to promote biosynthesis.
    Title: An Isoprene Lipid-Binding Protein Promotes Eukaryotic Coenzyme Q Biosynthesis.
  2. Yeast Coq9 controls deamination of coenzyme Q intermediates that derive from para-aminobenzoic acid.
    Title: Yeast Coq9 controls deamination of coenzyme Q intermediates that derive from para-aminobenzoic acid.
  3. Coq9p is a peripheral membrane protein on the matrix side of the mitochondrial inner membrane. A direct physical interaction was shown by the immunoprecipitation of HA-tagged Coq9 polypeptide with Coq4p, Coq5p, Coq6p and Coq7p.
    Title: Saccharomyces cerevisiae Coq9 polypeptide is a subunit of the mitochondrial coenzyme Q biosynthetic complex.
  4. Coq9 may catalyze a reaction in the coenzyme Q biosynthetic pathway or have a regulatory role similar to that proposed for Coq8
    Title: COQ9, a new gene required for the biosynthesis of coenzyme Q in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquinone biosynthetic process IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in ubiquinone-6 biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquinone biosynthesis protein COQ9
NP_013302.1
  • Protein required for ubiquinone biosynthesis and respiratory growth; localizes to matrix face of mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; ubiquinone is also known as coenzyme Q; human homolog COQ9 can complement yeast coq9 null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    549511..550293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182088.1 → NP_013302.1  TPA: ubiquinone biosynthesis protein COQ9 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013302.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYK3, Q05779
    UniProtKB/TrEMBL
    A0A7I9FMT6, A7A190, B3RH91, B5VNB9, C7GIT2, C8ZDG7, G2WJ32, N1P6T3
    Conserved Domains (1) summary
    COG5590
    Location:11 → 255
    COG5590; Ubiquinone biosynthesis protein COQ9 [Coenzyme transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05779.1

Gene LinkOut

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