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NNT1 S-adenosylmethionine-dependent methyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850991, updated on 5-May-2024

Summary

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Gene symbol
NNT1
Gene description
S-adenosylmethionine-dependent methyltransferase
Primary source
SGD:S000004275
Locus tag
YLR285W
See related
AllianceGenome:SGD:S000004275
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
EFM7
Summary
Enables N-terminal protein N-methyltransferase activity and protein-lysine N-methyltransferase activity. Involved in N-terminal peptidyl-glycine methylation; peptidyl-lysine dimethylation; and rDNA heterochromatin assembly. Located in cytoplasm. Orthologous to human METTL21C (methyltransferase 21C, AARS1 lysine). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (707360..708145)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Put7p Neighboring gene dodecenoyl-CoA isomerase Neighboring gene uncharacterized protein Neighboring gene chitinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Anderson RM, et al. Nature, 2003 May 8. PMID 12736687, Free PMC Article
  2. Calorie restriction extends yeast life span by lowering the level of NADH. Lin SJ, et al. Genes Dev, 2004 Jan 1. PMID 14724176, Free PMC Article
  3. Protein Methylation and Translation: Role of Lysine Modification on the Function of Yeast Elongation Factor 1A. White JT, et al. Biochemistry, 2019 Dec 10. PMID 31738538, Free PMC Article
  4. Characterization of Protein Methyltransferases Rkm1, Rkm4, Efm4, Efm7, Set5 and Hmt1 Reveals Extensive Post-Translational Modification. Winter DL, et al. J Mol Biol, 2018 Jan 5. PMID 29183786
  5. Comprehensive structural and substrate specificity classification of the Saccharomyces cerevisiae methyltransferome. Wlodarski T, et al. PLoS One, 2011. PMID 21858014, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that the methylation of lysine (Lys) in elongation factor 1A (eEF1A) by methyltransferase is conserved from yeast to human.
    Title: Novel N-terminal and Lysine Methyltransferases That Target Translation Elongation Factor 1A in Yeast and Human.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables N-terminal protein N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-terminal protein N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables S-adenosylmethionine-dependent methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-lysine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-lysine methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rDNA heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
S-adenosylmethionine-dependent methyltransferase
NP_013387.1
  • S-adenosylmethionine-dependent methyltransferase; novel N-terminal protein methyltransferase that trimethylates the N-terminal glycine residue (G2) and also dimethylates lysine (K3) on elongation factor eEF1A (Tef1p/Tef2p); has a role in rDNA silencing and in lifespan determination

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    707360..708145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182172.1 → NP_013387.1  TPA: S-adenosylmethionine-dependent methyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013387.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYS9, Q05874
    UniProtKB/TrEMBL
    A0A8H4BXF4, A7A1G6, C7GVS8, G2WJA7, N1NYI4
    Conserved Domains (1) summary
    COG3897
    Location:1 → 256
    Nnt1; Predicted nicotinamide N-methyase [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05874.1

Gene LinkOut

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