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STT4 1-phosphatidylinositol 4-kinase STT4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851014, updated on 5-May-2024

Summary

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Gene symbol
STT4
Gene description
1-phosphatidylinositol 4-kinase STT4
Primary source
SGD:S000004296
Locus tag
YLR305C
See related
AllianceGenome:SGD:S000004296
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 1-phosphatidylinositol 4-kinase activity. Involved in several processes, including autophagosome-lysosome fusion; microlipophagy; and phosphatidylinositol phosphate biosynthetic process. Located in plasma membrane. Orthologous to several human genes including PI4KA (phosphatidylinositol 4-kinase alpha). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (738161..743863, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene tRNA-Ile Neighboring gene aconitate hydratase ACO1 Neighboring gene NEDD8-conjugating protein UBC12 Neighboring gene chitin deacetylase CDA1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genetic screen for aminophospholipid transport mutants identifies the phosphatidylinositol 4-kinase, STT4p, as an essential component in phosphatidylserine metabolism. Trotter PJ, et al. J Biol Chem, 1998 May 22. PMID 9582361
  2. Cloning, characterization and identification of the gene encoding phosphatidylinositol 4-kinase. Pramanik A, et al. Cell Mol Biol (Noisy-le-grand), 1997 Nov. PMID 9449533
  3. Membrane-associated phosphatidylinositol kinase from Saccharomyces cerevisiae. McKenzie MA, et al. J Bacteriol, 1983 Oct. PMID 6311802, Free PMC Article
  4. Purification and characterization of phosphatidylinositol kinase from Saccharomyces cerevisiae. Belunis CJ, et al. J Biol Chem, 1988 Dec 15. PMID 2848810
  5. Pheromone-induced anisotropy in yeast plasma membrane phosphatidylinositol-4,5-bisphosphate distribution is required for MAPK signaling. Garrenton LS, et al. Proc Natl Acad Sci U S A, 2010 Jun 29. PMID 20547860, Free PMC Article

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Microautophagy in the yeast vacuole depends on the activities of phosphatidylinositol 4-kinases, Stt4p and Pik1p.
    Title: Microautophagy in the yeast vacuole depends on the activities of phosphatidylinositol 4-kinases, Stt4p and Pik1p.
  2. Stt4 is important for the process of autophagosome-vacuole fusion.
    Title: Essential and distinct roles of phosphatidylinositol 4-kinases, Pik1p and Stt4p, in yeast autophagy.
  3. inositol-containing sphingolipid metabolism controls PKC signaling by regulating access of the signaling lipids PI4P and phosphatidylinositol 4,5-bisphosphate to effector proteins on the plasma membrane
    Title: Interruption of inositol sphingolipid synthesis triggers Stt4p-dependent protein kinase C signaling.
  4. Ypp1 and Efr3 are required for the formation and architecture of Stt4 PIK patches and ultimately plasma membrane-based PtdIns4P signaling.
    Title: Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3.
  5. overexpression of STT4 suppresses the temperature-sensitive growth defect of ypp1 mutants.
    Title: Ypp1/YGR198w plays an essential role in phosphoinositide signalling at the plasma membrane.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol 4-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-phosphatidylinositol 4-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-phosphatidylinositol 4-kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagosome-lysosome fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to nitrogen starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microlipophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4-kinase STT4
NP_013408.1
  • Phosphatidylinositol-4-kinase; functions in Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization; required for autophagosome-vacuole fusion during autophagy and for lipophagy in stationary phase cells and during nitrogen starvation; localizes to plasma membrane and mitochondria in HTP studies

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    738161..743863 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182193.1 → NP_013408.1  TPA: 1-phosphatidylinositol 4-kinase STT4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013408.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYU8, P37297
    UniProtKB/TrEMBL
    B3RHI3, B5VNK6, N1NZK9
    Conserved Domains (1) summary
    COG5032
    Location:1 → 1900
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37297.1

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