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DIC1 Dic1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851063, updated on 13-Apr-2024

Summary

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Gene symbol
DIC1
Gene description
Dic1p
Primary source
SGD:S000004340
Locus tag
YLR348C
See related
AllianceGenome:SGD:S000004340
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables dicarboxylic acid transmembrane transporter activity. Involved in dicarboxylic acid transport. Located in mitochondrial envelope. Used to study childhood onset epileptic encephalopathy; mitochondrial DNA depletion syndrome; and mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome and paraganglioma. Orthologous to several human genes including SLC25A10 (solute carrier family 25 member 10). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (826977..827873, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Cis1p Neighboring gene karyopherin beta Neighboring gene sphingolipid homeostasis protein ORM2 Neighboring gene putative hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A protein structure prediction service in the ProGenGrid system. Mirto M, et al. Stud Health Technol Inform, 2008. PMID 18560115
  2. Biogenesis of yeast dicarboxylate carrier: the carrier signature facilitates translocation across the mitochondrial outer membrane. Zara V, et al. J Cell Sci, 2007 Dec 1. PMID 18032784
  3. Topography of the active site of the Saccharomyces cerevisiae plasmalemmal dicarboxylate transporter studied using lipophilic derivatives of its substrates. Aliverdieva DA, et al. Biochemistry (Mosc), 2007 Mar. PMID 17447879
  4. The mitochondrial dicarboxylate carrier is essential for the growth of Saccharomyces cerevisiae on ethanol or acetate as the sole carbon source. Palmieri L, et al. Mol Microbiol, 1999 Jan. PMID 10027973
  5. Identification of a novel gene encoding the yeast mitochondrial dicarboxylate transport protein via overexpression, purification, and characterization of its protein product. Kakhniashvili D, et al. J Biol Chem, 1997 Feb 14. PMID 9020177

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. each module of the dicarboxylate carrier contains sufficient targeting information for its transport across the outer mitochondrial membrane
    Title: The carboxyl-terminal third of the dicarboxylate carrier is crucial for productive association with the inner membrane twin-pore translocase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables dicarboxylic acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dicarboxylic acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables malate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxaloacetate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiosulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in dicarboxylic acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in malate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oxaloacetate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oxaloacetate(2-) transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphate ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in succinate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thiosulfate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Dic1p
NP_013452.1
  • Mitochondrial dicarboxylate carrier; integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    826977..827873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182237.1 → NP_013452.1  TPA: Dic1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013452.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYY7, P87332, Q06143
    UniProtKB/TrEMBL
    A0A6A5PWS6, A7A1M7, B3RHL8, C7GRX4, C8ZDV6, G2WJG7, N1NZN7
    Conserved Domains (1) summary
    pfam00153
    Location:20 → 94
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06143.1

Gene LinkOut

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