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ILV5 ketol-acid reductoisomerase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851069, updated on 5-May-2024

Summary

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Gene symbol
ILV5
Gene description
ketol-acid reductoisomerase
Primary source
SGD:S000004347
Locus tag
YLR355C
See related
AllianceGenome:SGD:S000004347
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables double-stranded DNA binding activity and ketol-acid reductoisomerase activity. Involved in branched-chain amino acid biosynthetic process and mitochondrial genome maintenance. Located in mitochondrial nucleoid. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (838066..839253, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Bud8p Neighboring gene sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1 Neighboring gene Atg33p Neighboring gene Rsc2p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Targeting of mitochondrial Saccharomyces cerevisiae Ilv5p to the cytosol and its effect on vicinal diketone formation in brewing. Omura F. Appl Microbiol Biotechnol, 2008 Mar. PMID 18193418
  2. Mutational bisection of the mitochondrial DNA stability and amino acid biosynthetic functions of ilv5p of budding yeast. Bateman JM, et al. Genetics, 2002 Jul. PMID 12136009, Free PMC Article
  3. Cloning and molecular analysis of two different ILV5 genes from a brewing strain of Saccharomyces cerevisiae. Xie Q, et al. Curr Genet, 1994 Nov-Dec. PMID 7874731
  4. Tandem integration of multiple ILV5 copies and elevated transcription in polyploid yeast. Mithieux SM, et al. Yeast, 1995 Apr 15. PMID 7785331
  5. Towards diacetyl-less brewers' yeast. Influence of ilv2 and ilv5 mutations. Gjermansen C, et al. J Basic Microbiol, 1988. PMID 3057172

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. direct binding of Ilv5p can aid in the maintenance and stabilization of mtDNA
    Title: Maintenance and stabilization of mtDNA can be facilitated by the DNA-binding activity of Ilv5p.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ketol-acid reductoisomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ketol-acid reductoisomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables ketol-acid reductoisomerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in branched-chain amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in branched-chain amino acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in isoleucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isoleucine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial genome maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitochondrial genome maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in valine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in valine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ketol-acid reductoisomerase
NP_013459.1
  • Acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    838066..839253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182244.1 → NP_013459.1  TPA: ketol-acid reductoisomerase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013459.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYZ3, P06168
    UniProtKB/TrEMBL
    A0A6A5PRQ6, A7A1N3, B3RHM4, B5VNP5, C7GRY0, C8ZDW2, E9P9Y3, G2WJH3, N1NYP1
    Conserved Domains (1) summary
    TIGR00465
    Location:75 → 395
    ilvC; ketol-acid reductoisomerase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06168.1

Gene LinkOut

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