BDH1 (R,R)-butanediol dehydrogenase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: BDH1
Gene description: (R,R)-butanediol dehydrogenase
Primary source: SGD:S000000056
Locus tag: YAL060W
See related: AllianceGenome:SGD:S000000056
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables (R,R)-butanediol dehydrogenase activity. Involved in butanediol biosynthetic process. Located in cytoplasm. Orthologous to human ZADH2 (zinc binding alcohol dehydrogenase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_001133.9 (35155..36303)

Chromosome I - NC_001133.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

While the use of purified Bdh1p allows the synthesis of enantiopure (2R,3R)-2,3-butanediol, (2R,3R)-2,3-pentanediol, (2R,3R)-2,3-hexanediol, and (3R,4R)-3,4-hexanediol, the use of the engineered strain (as an extract or as permeabilized cells) yields mixtures of the diols.
Title: Enantioselective Synthesis of Vicinal (R,R)-Diols by Saccharomyces cerevisiae Butanediol Dehydrogenase.
These data emphasize the role of Bdh1p in the metabolic remodeling associated with the transition from fermentation to respiration.
Title: Role of Saccharomyces cerevisiae oxidoreductases Bdh1p and Ara1p in the metabolism of acetoin and 2,3-butanediol.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables (R,R)-butanediol dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables (R,R)-butanediol dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables (R,R)-butanediol dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in alcohol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in butanediol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in butanediol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: (R,R)-butanediol dehydrogenase

NP_009341.2

EC 1.1.1.4

NAD-dependent (R,R)-butanediol dehydrogenase; catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001133.9 Reference assembly

Range

35155..36303

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178202.2 → NP_009341.2 TPA: (R,R)-butanediol dehydrogenase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009341.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VPF9, E9P8Z3, P39714

UniProtKB/TrEMBL

A0A7S8WHP6, G2W8H3, N1P924

Conserved Domains (1) summary

cd08233
Location:1 → 374

butanediol_DH_like; (2R,3R)-2,3-butanediol dehydrogenase