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GCV3 glycine decarboxylase subunit H [ Saccharomyces cerevisiae S288C ]

Gene ID: 851254, updated on 13-Apr-2024

Summary

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Gene symbol
GCV3
Gene description
glycine decarboxylase subunit H
Primary source
SGD:S000000042
Locus tag
YAL044C
See related
AllianceGenome:SGD:S000000042
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables lipoic acid binding activity. Involved in glycine catabolic process; one-carbon metabolic process; and protein lipoylation. Located in mitochondrion. Part of glycine cleavage complex. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human GCSH (glycine cleavage system protein H). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (57950..58462, complement)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene Bol3p Neighboring gene Bol1p Neighboring gene RNA-processing protein PTA1 Neighboring gene Erv46p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanism-Driven Metabolic Engineering for Bio-Based Production of Free R-Lipoic Acid in Saccharomyces cerevisiae Mitochondria. Chen B, et al. Front Bioeng Biotechnol, 2020. PMID 32974306, Free PMC Article
  2. The role of the Saccharomyces cerevisiae lipoate protein ligase homologue, Lip3, in lipoic acid synthesis. Hermes FA, et al. Yeast, 2013 Oct. PMID 23960015, Free PMC Article
  3. Regulation of the yeast glycine cleavage genes is responsive to the availability of multiple nutrients. Piper MD, et al. FEMS Yeast Res, 2002 Mar. PMID 12702322
  4. Control of expression of one-carbon metabolism genes of Saccharomyces cerevisiae is mediated by a tetrahydrofolate-responsive protein binding to a glycine regulatory region including a core 5'-CTTCTT-3' motif. Hong SP, et al. J Biol Chem, 1999 Apr 9. PMID 10187845
  5. Lipoic acid synthesis and attachment in yeast mitochondria. Schonauer MS, et al. J Biol Chem, 2009 Aug 28. PMID 19570983, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables lipoic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycine decarboxylation via glycine cleavage system IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine decarboxylation via glycine cleavage system IEA
Inferred from Electronic Annotation
more info
  
involved_in one-carbon metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein lipoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein lipoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glycine cleavage complex IEA
Inferred from Electronic Annotation
more info
  
part_of glycine cleavage complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glycine decarboxylase subunit H
NP_009355.3
  • H subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    57950..58462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178189.1 → NP_009355.3  TPA: glycine decarboxylase subunit H [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009355.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPH2, P39726
    UniProtKB/TrEMBL
    A0A6A5PV58, A7A0C2, B3LUY0, C7GPJ3, C8Z3E4, G2W8I6, N1P917
    Conserved Domains (1) summary
    TIGR00527
    Location:40 → 169
    gcvH; glycine cleavage system H protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39726.3

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