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ADE1 phosphoribosylaminoimidazolesuccinocarboxamide synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851272, updated on 17-May-2024

Summary

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Gene symbol
ADE1
Gene description
phosphoribosylaminoimidazolesuccinocarboxamide synthase
Primary source
FungiDB:YAR015W
Locus tag
YAR015W
See related
SGD:S000000070; AllianceGenome:SGD:S000000070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity. Involved in 'de novo' IMP biosynthetic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (169375..170295)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene tRNA-Ala Neighboring gene protein phosphatase regulator BUD14 Neighboring gene serine/threonine protein kinase KIN3 Neighboring gene serine/threonine protein kinase CDC15

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The structure of SAICAR synthase: an enzyme in the de novo pathway of purine nucleotide biosynthesis. Levdikov VM, et al. Structure, 1998 Mar 15. PMID 9551557
  2. Molecular cloning of the ADE1 gene of Saccharomyces cerevisiae and stability of the transformants. Dimock K, et al. Gene, 1984 Feb. PMID 6373504
  3. Enzymology of the pigmented adenine-requiring mutants of Saccharomyces and Schizosaccharomyces. Fisher CR. Biochem Biophys Res Commun, 1969 Feb 7. PMID 5767025
  4. [Cloning and physical mapping of the ADE1 gene of the yeast Saccharomyces cerevisiae]. Sasnauskas KV, et al. Genetika, 1986 Apr. PMID 3015720
  5. [Isolation and properties of phosphoribosyl-aminoimidazole-succinocarboxyamide-synthestase from Saccharomyces cerevisiae yeasts]. Ostanin KV, et al. Biokhimiia, 1989 Aug. PMID 2684279

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' IMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' IMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in purine nucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
phosphoribosylaminoimidazolesuccinocarboxamide synthase
NP_009409.1
  • N-succinyl-5-aminoimidazole-4-carboxamide ribotide synthetase; required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    169375..170295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178216.1 → NP_009409.1  TPA: phosphoribosylaminoimidazolesuccinocarboxamide synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009409.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPM4, P27616
    UniProtKB/TrEMBL
    A0A6A5PXX4, A7A0H3, B3LUT3, B5VDM5, C7GUF6, C8Z3I5, G2W8N6, N1P7M3
    Conserved Domains (1) summary
    PRK13961
    Location:1 → 305
    PRK13961; phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27616.2

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