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VMA1 H(+)-transporting V1 sector ATPase subunit A [ Saccharomyces cerevisiae S288C ]

Gene ID: 851342, updated on 5-May-2024

Summary

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Gene symbol
VMA1
Gene description
H(+)-transporting V1 sector ATPase subunit A
Primary source
SGD:S000002344
Locus tag
YDL185W
See related
AllianceGenome:SGD:S000002344
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CLS8; TFP1
Summary
Enables proton-transporting ATPase activity, rotational mechanism. Involved in cellular protein metabolic process and vacuolar acidification. Located in fungal-type vacuole membrane. Part of vacuolar proton-transporting V-type ATPase, V1 domain. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IID and developmental and epileptic encephalopathy 93. Orthologous to human ATP6V1A (ATPase H+ transporting V1 subunit A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (126787..130002)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene phosphoprotein phosphatase 2A catalytic subunit PPH22 Neighboring gene uncharacterized protein Neighboring gene ribosomal 60S subunit protein L41A Neighboring gene Mrx19p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A parasitic selfish gene that affects host promiscuity. Giraldo-Perez P, et al. Proc Biol Sci, 2013 Nov 7. PMID 24048156, Free PMC Article
  2. Conditional genomic rearrangement by designed meiotic recombination using VDE (PI-SceI) in yeast. Fukuda T, et al. Mol Genet Genomics, 2007 Oct. PMID 17587055
  3. Investigation of the mechanism of meiotic DNA cleavage by VMA1-derived endonuclease uncovers a meiotic alteration in chromatin structure around the target site. Fukuda T, et al. Eukaryot Cell, 2006 Jun. PMID 16757746, Free PMC Article
  4. Involvement of the nonhomologous region of subunit A of the yeast V-ATPase in coupling and in vivo dissociation. Shao E, et al. J Biol Chem, 2004 Nov 19. PMID 15355963
  5. Mutational analysis of the non-homologous region of subunit A of the yeast V-ATPase. Shao E, et al. J Biol Chem, 2003 Apr 11. PMID 12569096

See all (203) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of function of the vacuolar H-ATPase (vma1) or a defect in the biosynthesis of the osmolyte glycerol (gpd1) caused a prolonged repression of housekeeping genes and a delay in gene activation and adaptation towards salt stress.
    Title: Coordinated gene regulation in the initial phase of salt stress adaptation.
  2. recruitment of Dmc1p and Rad51p to the TFP1-induced double-strand break repair site
    Title: Recruitment of RecA homologs Dmc1p and Rad51p to the double-strand break repair site initiated by meiosis-specific endonuclease VDE (PI-SceI).
  3. Study suggests that nucleosome positioning or occupancy around the VDE recognition site by itself is not the sole mechanism for the regulation of meiosis-specific DNA cleavage by VDE and that other mechanisms are involved in the regulation.
    Title: Investigation of the mechanism of meiotic DNA cleavage by VMA1-derived endonuclease uncovers a meiotic alteration in chromatin structure around the target site.
  4. the nonhomologous region of subunit A of the yeast V-ATPase is involved in coupling and in vivo dissociation
    Title: Involvement of the nonhomologous region of subunit A of the yeast V-ATPase in coupling and in vivo dissociation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
enables proton-transporting ATP synthase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
enables proton-transporting ATPase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton-transporting ATPase activity, rotational mechanism IDA
Inferred from Direct Assay
more info
 PubMed 
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ATP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intein-mediated protein splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in intron homing IEA
Inferred from Electronic Annotation
more info
  
involved_in protein metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuolar acidification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
part_of vacuolar proton-transporting V-type ATPase, V1 domain IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
H(+)-transporting V1 sector ATPase subunit A
NP_010096.1
  • Subunit A of the V1 peripheral membrane domain of V-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    126787..130002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180245.1 → NP_010096.1  TPA: H(+)-transporting V1 sector ATPase subunit A [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010096.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRG7, O74301, P17255, Q9Y7W5
    UniProtKB/TrEMBL
    A0A8H8UMB3, C8Z6B9, G2WBY0, N1P711
    Conserved Domains (2) summary
    TIGR01042
    Location:733 → 1063
    V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
    pfam05203
    Location:284 → 736
    Hom_end_hint; Hom_end-associated Hint
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17255.3

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