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HXT15 hexose transporter HXT15 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851352, updated on 11-Apr-2024

Summary

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Gene symbol
HXT15
Gene description
hexose transporter HXT15
Primary source
SGD:S000002404
Locus tag
YDL245C
See related
AllianceGenome:SGD:S000002404
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HLT2
Summary
Enables fructose transmembrane transporter activity; glucose transmembrane transporter activity; and mannose transmembrane transporter activity. Involved in carbohydrate transport. Located in cell periphery. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (11657..13360, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene alpha-glucoside permease Neighboring gene L-iditol 2-dehydrogenase SOR2 Neighboring gene 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase Neighboring gene putative aryl-alcohol dehydrogenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequencing analysis of a 4.1 kb subtelomeric region from yeast chromosome IV identifies HXT15, a new member of the hexose transporter family. Bargues M, et al. Yeast, 1996 Sep. PMID 8896264
  2. Improvement in D-xylose utilization and isobutanol production in S. cerevisiae by adaptive laboratory evolution and rational engineering. Promdonkoy P, et al. J Ind Microbiol Biotechnol, 2020 Jul. PMID 32430798
  3. Transcription of hexose transporters of Saccharomyces cerevisiae is affected by change in oxygen provision. Rintala E, et al. BMC Microbiol, 2008 Mar 28. PMID 18373847, Free PMC Article
  4. Hxt13, Hxt15, Hxt16 and Hxt17 from Saccharomyces cerevisiae represent a novel type of polyol transporters. Jordan P, et al. Sci Rep, 2016 Mar 21. PMID 26996892, Free PMC Article
  5. Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae. Wieczorke R, et al. FEBS Lett, 1999 Dec 31. PMID 10618490

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables carbohydrate:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructose transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glucose transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables glucose transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mannose transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in glucose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in hexose transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mannitol transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mannose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in organic substance transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sorbitol transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xylitol transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
hexose transporter HXT15
NP_010036.1
  • Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    11657..13360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180305.1 → NP_010036.1  TPA: hexose transporter HXT15 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010036.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRB2, P54854
    UniProtKB/TrEMBL
    A0A8H8UM59, A6ZX90, N1PAD0
    Conserved Domains (1) summary
    cd17356
    Location:62 → 524
    MFS_HXT; Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54854.1

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