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PMT5 putative dolichyl-phosphate-mannose-protein mannosyltransferase PMT5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851464, updated on 11-Apr-2024

Summary

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Gene symbol
PMT5
Gene description
putative dolichyl-phosphate-mannose-protein mannosyltransferase PMT5
Primary source
SGD:S000002251
Locus tag
YDL093W
See related
AllianceGenome:SGD:S000002251
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Predicted to be involved in protein O-linked mannosylation. Located in endoplasmic reticulum. Part of dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex and dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex. Orthologous to human SDF2L1 (stromal cell derived factor 2 like 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (289909..292140)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene proteasome regulatory particle lid subunit RPN6 Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase PMT1 Neighboring gene RNA-binding signal recognition particle subunit SRP14 Neighboring gene Ubx3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional implications of MIR domains in protein O-mannosylation. Chiapparino A, et al. Elife, 2020 Dec 24. PMID 33357379, Free PMC Article
  2. Systematic screening of glycosylation- and trafficking-associated gene knockouts in Saccharomyces cerevisiae identifies mutants with improved heterologous exocellulase activity and host secretion. Wang TY, et al. BMC Biotechnol, 2013 Sep 3. PMID 24004614, Free PMC Article
  3. The sequence of a 16,691 bp segment of Saccharomyces cerevisiae chromosome IV identifies the DUN1, PMT1, PMT5, SRP14 and DPR1 genes, and five new open reading frames. Boskovic J, et al. Yeast, 1996 Oct. PMID 8923743
  4. Identification of a novel lysophospholipid acyltransferase in Saccharomyces cerevisiae. Jain S, et al. J Biol Chem, 2007 Oct 19. PMID 17726007
  5. Members of the evolutionarily conserved PMT family of protein O-mannosyltransferases form distinct protein complexes among themselves. Girrbach V, et al. J Biol Chem, 2003 Apr 4. PMID 12551906

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein O-linked mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked mannosylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative dolichyl-phosphate-mannose-protein mannosyltransferase PMT5
NP_010190.1
  • Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    289909..292140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180152.1 → NP_010190.1  TPA: putative dolichyl-phosphate-mannose-protein mannosyltransferase PMT5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010190.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRQ5, P52867, Q92181
    UniProtKB/TrEMBL
    A0A8H8UMJ5, A6ZXN4, G2WC69
    Conserved Domains (1) summary
    COG1928
    Location:22 → 729
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52867.1

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