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MDH3 malate dehydrogenase MDH3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851481, updated on 17-May-2024

Summary

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Gene symbol
MDH3
Gene description
malate dehydrogenase MDH3
Primary source
FungiDB:YDL078C
Locus tag
YDL078C
See related
SGD:S000002236; AllianceGenome:SGD:S000002236
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables L-malate dehydrogenase activity and mRNA binding activity. Involved in NADH regeneration and fatty acid beta-oxidation. Located in peroxisomal matrix. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MDH3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (315357..316388, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene branched-chain-2-oxoacid decarboxylase THI3 Neighboring gene putative serine/threonine protein kinase MRK1 Neighboring gene Vam6p Neighboring gene Rxt3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of glyoxysomal malate dehydrogenase (MDH3) from Saccharomyces cerevisiae. Moriyama S, et al. Acta Crystallogr F Struct Biol Commun, 2018 Oct 1. PMID 30279312, Free PMC Article
  2. Metabolic effects of altering redundant targeting signals for yeast mitochondrial malate dehydrogenase. Small WC, et al. Arch Biochem Biophys, 1997 Aug 1. PMID 9244381
  3. Analysis of the carboxyl-terminal peroxisomal targeting signal 1 in a homologous context in Saccharomyces cerevisiae. Elgersma Y, et al. J Biol Chem, 1996 Oct 18. PMID 8824293
  4. Expression and function of a mislocalized form of peroxisomal malate dehydrogenase (MDH3) in yeast. McAlister-Henn L, et al. J Biol Chem, 1995 Sep 8. PMID 7673155
  5. Mutation in the peroxin-coding gene PEX22 contributing to high malate production in Saccharomyces cerevisiae. Negoro H, et al. J Biosci Bioeng, 2018 Feb. PMID 28919252

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure of glyoxysomal malate dehydrogenase (MDH3) from Saccharomyces cerevisiae has been presented.
    Title: Structure of glyoxysomal malate dehydrogenase (MDH3) from Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables L-malate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-malate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-malate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-malate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NADH regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glyoxylate cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in malate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
malate dehydrogenase MDH3
NP_010205.1
  • Peroxisomal malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle; mutation in human homolog MDH2 causes early-onset severe encephalopathy

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    315357..316388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180137.1 → NP_010205.1  TPA: malate dehydrogenase MDH3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010205.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRS1, P32419, Q12689
    UniProtKB/TrEMBL
    A0A6A5Q0X0, A6ZXQ0, B3LGX3, B5VFJ0, C7GJN4, C8Z4J2, G2WC85, N1P602
    Conserved Domains (1) summary
    TIGR01772
    Location:3 → 339
    MDH_euk_gproteo; malate dehydrogenase, NAD-dependent
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32419.3

Gene LinkOut

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