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GPM2 phosphoglycerate mutase family protein GPM2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851541, updated on 11-Apr-2024

Summary

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Gene symbol
GPM2
Gene description
phosphoglycerate mutase family protein GPM2
Primary source
SGD:S000002179
Locus tag
YDL021W
See related
AllianceGenome:SGD:S000002179
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable phosphoglycerate mutase activity. Predicted to be involved in glycolytic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in familial erythrocytosis 8. Orthologous to human BPGM (bisphosphoglycerate mutase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (413953..414888)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA-Ala Neighboring gene glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Neighboring gene stress-regulated transcription factor RPN4 Neighboring gene oxysterol-binding protein related protein OSH2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional response to deletion of the phosphatidylserine decarboxylase Psd1p in the yeast Saccharomyces cerevisiae. Gsell M, et al. PLoS One, 2013. PMID 24146988, Free PMC Article
  2. Time-dependent regulation analysis dissects shifts between metabolic and gene-expression regulation during nitrogen starvation in baker's yeast. van Eunen K, et al. FEBS J, 2009 Oct. PMID 19691496
  3. Cnm1 mediates nucleus-mitochondria contact site formation in response to phospholipid levels. Eisenberg-Bord M, et al. J Cell Biol, 2021 Nov 1. PMID 34694322, Free PMC Article
  4. Investigation of two yeast genes encoding putative isoenzymes of phosphoglycerate mutase. Heinisch JJ, et al. Yeast, 1998 Feb. PMID 9544241
  5. Kel1 is a phosphorylation-regulated noise suppressor of the pheromone signaling pathway. Garcia I, et al. Cell Rep, 2021 Dec 28. PMID 34965431

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity IEA
Inferred from Electronic Annotation
more info
  
enables intramolecular phosphotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables phosphoglycerate mutase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphoglycerate mutase family protein GPM2
NP_010263.1
  • Nonfunctional homolog of Gpm1p phosphoglycerate mutase; if functional, would convert 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; GPM2 has a paralog, GPM3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    413953..414888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180080.1 → NP_010263.1  TPA: phosphoglycerate mutase family protein GPM2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010263.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRW9, Q12008
    UniProtKB/TrEMBL
    A0A6A5PZ95, A6ZXU8, B3LGS6, B5VFP3, C7GW58, G2WCD4, N1P7V6
    Conserved Domains (1) summary
    COG0588
    Location:9 → 292
    GpmA; Phosphoglycerate mutase (BPG-dependent) [Carbohydrate transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12008.1

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