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KCS1 inositol polyphosphate kinase KCS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851580, updated on 13-Apr-2024

Summary

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Gene symbol
KCS1
Gene description
inositol polyphosphate kinase KCS1
Primary source
SGD:S000002424
Locus tag
YDR017C
See related
AllianceGenome:SGD:S000002424
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables inositol heptakisphosphate kinase activity; inositol hexakisphosphate kinase activity; and inositol-1,3,4,5,6-pentakisphosphate kinase activity. Involved in inositol phosphate biosynthetic process and regulation of inositol phosphate biosynthetic process. Located in cytoplasm. Orthologous to human IP6K1 (inositol hexakisphosphate kinase 1); IP6K2 (inositol hexakisphosphate kinase 2); and IP6K3 (inositol hexakisphosphate kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (479115..482267, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Hed1p Neighboring gene Dad1p Neighboring gene putative acyltransferase Neighboring gene glycine decarboxylase subunit T

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Signal transduction during environmental stress: InsP8 operates within highly restricted contexts. Choi K, et al. Cell Signal, 2005 Dec. PMID 15936174
  2. Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in Saccharomyces cerevisiae. Thota SG, et al. Biochem J, 2015 Feb 15. PMID 25423617, Free PMC Article
  3. Inositol pyrophosphates modulate S phase progression after pheromone-induced arrest in Saccharomyces cerevisiae. Banfic H, et al. J Biol Chem, 2013 Jan 18. PMID 23179856, Free PMC Article
  4. Genetic interaction between ribosome biogenesis and inositol polyphosphate metabolism in Saccharomyces cerevisiae. Horigome C, et al. Biosci Biotechnol Biochem, 2009 Feb. PMID 19202276
  5. Inositol pyrophosphates regulate endocytic trafficking. Saiardi A, et al. Proc Natl Acad Sci U S A, 2002 Oct 29. PMID 12391334, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in Saccharomyces cerevisiae via KCS1 activity.
    Title: Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in Saccharomyces cerevisiae.
  2. Plc1p, Arg82p, and Kcs1p are enzymes involved in inositol pyrophosphate synthesis and are essential for phosphate regulation and polyphosphate accumulation
    Title: Plc1p, Arg82p, and Kcs1p, enzymes involved in inositol pyrophosphate synthesis, are essential for phosphate regulation and polyphosphate accumulation in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables inositol heptakisphosphate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol hexakisphosphate 1-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol hexakisphosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol hexakisphosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol hexakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol hexakisphosphate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-1,3,4,5,6-pentakisphosphate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-1,3,4,5,6-pentakisphosphate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inositol phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in inositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in inositol phosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of inositol phosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
inositol polyphosphate kinase KCS1
NP_010300.3
  • Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response, RNA polymerase I-mediated rRNA transcription and telomere maintenance; phosphorylated by the AMPK Snf1p, leading to reduced levels of pyrophosphorylated IP7, increased filamentous and invasive growth and increased cell elongation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    479115..482267 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180325.3 → NP_010300.3  TPA: inositol polyphosphate kinase KCS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010300.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS03, P89899, Q12494, Q7LGR2
    UniProtKB/TrEMBL
    A0A8H8UMT7, A6ZXY1, C8Z4T7, N1P6B8
    Conserved Domains (1) summary
    pfam03770
    Location:759 → 957
    IPK; Inositol polyphosphate kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12494.1

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