U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SES1 serine--tRNA ligase SES1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851587, updated on 17-May-2024

Summary

Go to the top of the page Help
Gene symbol
SES1
Gene description
serine--tRNA ligase SES1
Primary source
FungiDB:YDR023W
Locus tag
YDR023W
See related
SGD:S000002430; AllianceGenome:SGD:S000002430
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables serine-tRNA ligase activity. Involved in seryl-tRNA aminoacylation. Located in cytoplasmic stress granule. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human SARS1 (seryl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (489508..490896)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Atg31p Neighboring gene tRNA-Val Neighboring gene ribosomal 40S subunit protein S11A Neighboring gene Nsi1p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Shuffling of discrete tRNASer regions reveals differently utilized identity elements in yeast and methanogenic archaea. Gruic-Sovulj I, et al. J Mol Biol, 2006 Aug 4. PMID 16822522
  2. tRNA-dependent amino acid discrimination by yeast seryl-tRNA synthetase. Gruic-Sovulj I, et al. Eur J Biochem, 2002 Nov. PMID 12392560
  3. Characterization of yeast seryl-tRNA synthetase active site mutants with improved discrimination against substrate analogues. Landeka I, et al. Biochim Biophys Acta, 2000 Jul 14. PMID 11004561
  4. C-terminal truncation of yeast SerRS is toxic for Saccharomyces cerevisiae due to altered mechanism of substrate recognition. Lenhard B, et al. FEBS Lett, 1998 Nov 20. PMID 9845329
  5. Only one nucleotide insertion to the long variable arm confers an efficient serine acceptor activity upon Saccharomyces cerevisiae tRNA(Leu) in vitro. Himeno H, et al. J Mol Biol, 1997 May 16. PMID 9175855

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity, acting on a tRNA IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of tRNA methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in seryl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in seryl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in seryl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
serine--tRNA ligase SES1
NP_010306.1
  • Cytosolic seryl-tRNA synthetase; class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate; copurifies with Abp140p in an RNA-dependent manner and stimulates 3-methylcytidine (m3C) modification of residue 32 of the tRNA anticodon loop of tRNA-Ser; interacts with peroxin Pex21p

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    489508..490896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180331.1 → NP_010306.1  TPA: serine--tRNA ligase SES1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010306.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS09, P07284
    UniProtKB/TrEMBL
    A0A6A5Q212, A6ZXY7, B3LGP1, C7GLX3, C8Z4U3, G2WAD0, N1P628
    Conserved Domains (1) summary
    PLN02678
    Location:1 → 449
    PLN02678; seryl-tRNA synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07284.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous