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ALT2 alanine transaminase ALT2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851690, updated on 17-May-2024

Summary

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Gene symbol
ALT2
Gene description
alanine transaminase ALT2
Primary source
FungiDB:YDR111C
Locus tag
YDR111C
See related
SGD:S000002518; AllianceGenome:SGD:S000002518
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable pyridoxal phosphate binding activity and transaminase activity. Predicted to be involved in L-alanine catabolic process and biosynthetic process. Located in cytoplasm and nucleus. Orthologous to several human genes including GPT (glutamic--pyruvic transaminase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ALT2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (678241..679764, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative phosphotransferase Neighboring gene replication fork barrier binding protein FOB1 Neighboring gene securin Neighboring gene uncharacterized protein Neighboring gene putative mitochondrial 54S ribosomal protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Saccharomyces cerevisiae Differential Functionalization of Presumed ScALT1 and ScALT2 Alanine Transaminases Has Been Driven by Diversification of Pyridoxal Phosphate Interactions. Rojas-Ortega E, et al. Front Microbiol, 2018. PMID 29867852, Free PMC Article
  2. ALT1-encoded alanine aminotransferase plays a central role in the metabolism of alanine in Saccharomyces cerevisiae. García-Campusano F, et al. Can J Microbiol, 2009 Apr. PMID 19396236
  3. Paralogous ALT1 and ALT2 retention and diversification have generated catalytically active and inactive aminotransferases in Saccharomyces cerevisiae. Peñalosa-Ruiz G, et al. PLoS One, 2012. PMID 23049841, Free PMC Article
  4. Alanine Represses γ-Aminobutyric Acid Utilization and Induces Alanine Transaminase Required for Mitochondrial Function in Saccharomyces cerevisiae. Márquez D, et al. Front Microbiol, 2021. PMID 34421848, Free PMC Article
  5. Metabolic-flux and network analysis in fourteen hemiascomycetous yeasts. Blank LM, et al. FEMS Yeast Res, 2005 Apr. PMID 15780654

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Paralogous ALT1 and ALT2 retention and diversification have generated catalytically active and inactive aminotransferases in Saccharomyces cerevisiae
    Title: Paralogous ALT1 and ALT2 retention and diversification have generated catalytically active and inactive aminotransferases in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables L-alanine:2-oxoglutarate aminotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-alanine:2-oxoglutarate aminotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-alanine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alanine transaminase ALT2
NP_010396.1
  • Catalytically inactive alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p; ALT2 has a paralog, ALT1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    678241..679764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180419.1 → NP_010396.1  TPA: alanine transaminase ALT2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010396.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS97, P52892, Q66RF8
    UniProtKB/TrEMBL
    A0A8H8UN25, A6ZY74, B3LGG4, C8Z527, G2WAL4, N1P6L1
    Conserved Domains (1) summary
    PTZ00377
    Location:26 → 505
    PTZ00377; alanine aminotransferase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52892.1

Gene LinkOut

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