ARO1 pentafunctional protein ARO1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ARO1
Gene description: pentafunctional protein ARO1p
Primary source: SGD:S000002534
Locus tag: YDR127W
See related: AllianceGenome:SGD:S000002534
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables several functions, including 3-phosphoshikimate 1-carboxyvinyltransferase activity; carbon-oxygen lyase activity; and shikimate 3-dehydrogenase (NADP+) activity. Predicted to be involved in chorismate biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (704484..709250)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sequence comparison between the target proteins, i.e., the plant EPSPS and the yeast orthologous protein Aro1, predicted that yeast would be resistant to glyphosate. However, the growth variation seen in the subset of yeast tested was not due to polymorphisms within Aro1, instead, it was caused by genetic variation in an ABC multiple drug transporter, Pdr5, and an amino acid permease, Dip5
Title: Genetic variation in Dip5, an amino acid permease, and Pdr5, a multiple drug transporter, regulates glyphosate resistance in S. cerevisiae.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3-dehydroquinate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-dehydroquinate dehydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-dehydroquinate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables 3-dehydroquinate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-dehydroquinate synthase activity	IEA Inferred from Electronic Annotation more info
enables 3-phosphoshikimate 1-carboxyvinyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-phosphoshikimate 1-carboxyvinyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-phosphoshikimate 1-carboxyvinyltransferase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables shikimate 3-dehydrogenase (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables shikimate 3-dehydrogenase (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables shikimate 3-dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables shikimate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables shikimate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables shikimate kinase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in aromatic amino acid family biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in chorismate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chorismate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in chorismate biosynthetic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pentafunctional protein ARO1p

NP_010412.1

EC 1.1.1.25

EC 2.5.1.19

EC 2.7.1.71

EC 4.2.1.10

EC 4.2.3.4

Pentafunctional arom protein; catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

704484..709250

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180435.1 → NP_010412.1 TPA: pentafunctional protein ARO1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010412.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C8Z543, D6VSB3, P08566

UniProtKB/TrEMBL

A0A8H8UN41

Conserved Domains (5) summary

COG0703
Location:887 → 1046

AroK; Shikimate kinase [Amino acid transport and metabolism]

TIGR01093
Location:1076 → 1298

aroD; 3-dehydroquinate dehydratase, type I

TIGR01357
Location:13 → 399

aroB; 3-dehydroquinate synthase

TIGR01809
Location:1302 → 1585

Shik-DH-AROM; shikimate-5-dehydrogenase, fungal AROM-type

pfam00275
Location:410 → 865

EPSP_synthase; EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)