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SDH4 succinate dehydrogenase membrane anchor subunit SDH4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851758, updated on 11-Apr-2024

Summary

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Gene symbol
SDH4
Gene description
succinate dehydrogenase membrane anchor subunit SDH4
Primary source
SGD:S000002585
Locus tag
YDR178W
See related
AllianceGenome:SGD:S000002585
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ACN18
Summary
Contributes to succinate dehydrogenase (ubiquinone) activity. Involved in cellular respiration. Located in mitochondrion. Used to study hypertrophic cardiomyopathy; mitochondrial complex II deficiency; and paraganglioma. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHD (succinate dehydrogenase complex subunit D). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (817950..818495)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene histone acetyltransferase NGG1 Neighboring gene E2 ubiquitin-conjugating protein UBC1 Neighboring gene Csn9p Neighboring gene Nvj3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutation of the heme axial ligand of Escherichia coli succinate-quinone reductase: implications for heme ligation in mitochondrial complex II from yeast. Maklashina E, et al. Biochim Biophys Acta, 2010 Jun-Jul. PMID 20100456, Free PMC Article
  2. The role of Sdh4p Tyr-89 in ubiquinone reduction by the Saccharomyces cerevisiae succinate dehydrogenase. Silkin Y, et al. Biochim Biophys Acta, 2007 Feb. PMID 17208193
  3. The Quinone-binding sites of the Saccharomyces cerevisiae succinate-ubiquinone oxidoreductase. Oyedotun KS, et al. J Biol Chem, 2001 May 18. PMID 11279023
  4. Isolation and characterization of the Saccharomyces cerevisiae SDH4 gene encoding a membrane anchor subunit of succinate dehydrogenase. Bullis BL, et al. J Biol Chem, 1994 Mar 4. PMID 8120006
  5. A recessive homozygous p.Asp92Gly SDHD mutation causes prenatal cardiomyopathy and a severe mitochondrial complex II deficiency. Alston CL, et al. Hum Genet, 2015 Aug. PMID 26008905, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Alternative SDH subunits have been identified in the genome; S. cerevisiae contains one paralog of the Sdh3p subunit, Shh3p (YMR118c), and two paralogs of the Sdh4p subunit, Shh4p (YLR164w) and Tim18p (YOR297c).
    Title: Expression of Saccharomyces cerevisiae Sdh3p and Sdh4p paralogs results in catalytically active succinate dehydrogenase isoenzymes.
  2. Study provides novel insight into the metabolic effects of SDH3 and SDH4 dysfunction and highlights the effectiveness of metabolic footprinting for examining complex disorders, such as mitochondrial diseases.
    Title: Mutations in the Saccharomyces cerevisiae succinate dehydrogenase result in distinct metabolic phenotypes revealed through (1)H NMR-based metabolic footprinting.
  3. Cth2 protein recruits the Dhh1 helicase to ARE-containing mRNAs to promote SDH4 mRNA decay
    Title: The Cth2 ARE-binding protein recruits the Dhh1 helicase to promote the decay of succinate dehydrogenase SDH4 mRNA in response to iron deficiency.
  4. Our results support a role for Tyr-89 in the protonation of ubiquinone and argue that the generation of reactive oxygen species is not causative of tumor formation.
    Title: The role of Sdh4p Tyr-89 in ubiquinone reduction by the Saccharomyces cerevisiae succinate dehydrogenase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables quinone binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquinone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial electron transport, succinate to ubiquinone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, succinate to ubiquinone TAS
Traceable Author Statement
more info
 PubMed 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial envelope IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) TAS
Traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
succinate dehydrogenase membrane anchor subunit SDH4
NP_010463.1
  • Membrane anchor subunit of succinate dehydrogenase (SDH); involved in coupling the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; has similarity to human SDH subunit D (SDHD), which is implicated in paraganglioma

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    817950..818495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180485.1 → NP_010463.1  TPA: succinate dehydrogenase membrane anchor subunit SDH4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010463.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSG0, P37298
    UniProtKB/TrEMBL
    A0A6A5PZQ2, A6ZYD6, B3LGA5, C7GN19, C8Z591, G2WAS6, N1P4W3
    Conserved Domains (1) summary
    pfam05328
    Location:34 → 167
    CybS; succinate dehydrogenase cytochrome B small subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37298.1

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