ADK1 adenylate kinase ADK1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: ADK1
Gene description: adenylate kinase ADK1
Primary source: SGD:S000002634
Locus tag: YDR226W
See related: AllianceGenome:SGD:S000002634
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: AKY1; AKY2
Summary: Enables DNA replication origin binding activity and adenylate kinase activity. Involved in ADP biosynthetic process; DNA replication initiation; and pre-replicative complex assembly. Located in mitochondrial intermembrane space. Human ortholog(s) of this gene implicated in reticular dysgenesis. Orthologous to human AK2 (adenylate kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Adk1p regulates ATP metabolism on pre-RC proteins to promote pre-RC assembly and activation.
Title: ATP-dependent pre-replicative complex assembly is facilitated by Adk1p in budding yeast.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA replication origin binding	IDA Inferred from Direct Assay more info	PubMed
enables adenylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylate kinase activity	IEA Inferred from Electronic Annotation more info
enables adenylate kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ADP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ADP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in AMP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ATP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in DNA replication initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleoside monophosphate phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in nucleotide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pre-replicative complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_010512.1

Adenylate kinase, required for purine metabolism; controls ATP homeostasis; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress; mutations affecting Adk1p catalytic activity deregulate expression of phosphate utilization genes PHO5 and PHO84; human homolog AK1 can complement yeast adk1 mutant