FMN1 riboflavin kinase [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: FMN1
Gene description: riboflavin kinase
Primary source: SGD:S000002644
Locus tag: YDR236C
See related: AllianceGenome:SGD:S000002644
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables riboflavin kinase activity. Involved in FMN biosynthetic process. Located in mitochondrial inner membrane. Used to study cancer. Orthologous to human RFK (riboflavin kinase). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables riboflavin kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables riboflavin kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables riboflavin kinase activity	IEA Inferred from Electronic Annotation more info
enables riboflavin kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in FMN biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in FMN biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in FMN biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in FMN biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in riboflavin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in riboflavin metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_010522.1

Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane; human RFK functionally complements the lethality of the null mutation