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CTA1 catalase A [ Saccharomyces cerevisiae S288C ]

Gene ID: 851843, updated on 17-May-2024

Summary

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Gene symbol
CTA1
Gene description
catalase A
Primary source
FungiDB:YDR256C
Locus tag
YDR256C
See related
SGD:S000002664; AllianceGenome:SGD:S000002664
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables catalase activity. Involved in age-dependent response to reactive oxygen species and hydrogen peroxide catabolic process. Located in mitochondrial matrix and peroxisomal matrix. Human ortholog(s) of this gene implicated in several diseases, including acatalasia; eye disease (multiple); lung disease (multiple); osteonecrosis; and pseudoxanthoma elasticum. Orthologous to human CAT (catalase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CTA1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (968133..969680, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Chl4p Neighboring gene ubiquitin-protein ligase RMD5 Neighboring gene ribosomal lysine N-methyltransferase Neighboring gene chaperone ATPase HSP78

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Oxidative stress response to menadione and cumene hydroperoxide in the opportunistic fungal pathogen Candida glabrata. Cuéllar-Cruz M, et al. Mem Inst Oswaldo Cruz, 2009 Jul. PMID 19722092
  2. Dual targeting of yeast catalase A to peroxisomes and mitochondria. Petrova VY, et al. Biochem J, 2004 Jun 1. PMID 14998369, Free PMC Article
  3. Structure of catalase-A from Saccharomyces cerevisiae. Maté MJ, et al. J Mol Biol, 1999 Feb 12. PMID 9931255
  4. Crystallization and preliminary structural analysis of catalase A from Saccharomyces cerevisiae. Berthet S, et al. Protein Sci, 1997 Feb. PMID 9041655, Free PMC Article
  5. A Saccharomyces cerevisiae upstream activating sequence mediates induction of peroxisome proliferation by fatty acids. Filipits M, et al. Gene, 1993 Sep 30. PMID 8406042

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Ile264 amino acid residue in Pex5, which is adjacent to the FxxxW diaromatic domain that was previously shown to be crucial for recognizing AOx and Cat2 as cargos, is also important for the efficient import of Fox2 and Cta1.
    Title: The budding yeast Pex5p receptor directs Fox2p and Cta1p into peroxisomes via its N-terminal region near the FxxxW domain.
  2. MET18 deficiency diminished the replicative capacity of yeast cells as evidenced by the shortened replicative lifespan, which can be restored by CTT1 overexpression, but not by CTA1, in the MET18-deficient cells.
    Title: MET18 Deficiency Increases the Sensitivity of Yeast to Oxidative Stress and Shortens Replicative Lifespan by Inhibiting Catalase Activity.
  3. Ccp1 responds to respiration-derived H2O2 via a previously unidentified mechanism involving H2O2-activated heme transfer to apoCta1
    Title: Respiration triggers heme transfer from cytochrome c peroxidase to catalase in yeast mitochondria.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables catalase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables catalase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables catalase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables catalase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in hydrogen peroxide catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in hydrogen peroxide catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in hydrogen peroxide catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to hydrogen peroxide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisomal matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
catalase A
NP_010542.1
  • Catalase A; breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    968133..969680 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180564.1 → NP_010542.1  TPA: catalase A [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010542.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSN6, E9P947, P15202
    UniProtKB/TrEMBL
    A0A6A5PZS8, A6ZYK8, B3LG34, C7GTJ1, C8Z5G8, G2WAZ9, N1P8H9
    Conserved Domains (1) summary
    cd08157
    Location:47 → 502
    catalase_fungal; Fungal catalases similar to yeast catalases A and T
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15202.1

Gene LinkOut

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