U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CTS2 putative chitinase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851977, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Gene symbol
CTS2
Gene description
putative chitinase
Primary source
SGD:S000002779
Locus tag
YDR371W
See related
AllianceGenome:SGD:S000002779
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable chitin binding activity and chitinase activity. Involved in sporulation resulting in formation of a cellular spore. Located in cytoplasm. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIT1 (chitinase 1) and CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1219413..1220948)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Xrs2p Neighboring gene Dxo1p Neighboring gene Vps74p Neighboring gene frequenin

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. An Ashbya gossypii cts2 mutant deficient in a sporulation-specific chitinase can be complemented by Candida albicans CHT4. Dünkler A, et al. Microbiol Res, 2008. PMID 18809304
  2. Candida albicans CHT3 encodes the functional homolog of the Cts1 chitinase of Saccharomyces cerevisiae. Dünkler A, et al. Fungal Genet Biol, 2005 Nov. PMID 16214381
  3. Sequestration of mRNAs Modulates the Timing of Translation during Meiosis in Budding Yeast. Jin L, et al. Mol Cell Biol, 2015 Oct. PMID 26217015, Free PMC Article
  4. Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity. Roelants FM, et al. Mol Biol Cell, 2002 Sep. PMID 12221112, Free PMC Article
  5. A conserved deubiquitinating enzyme controls cell growth by regulating RNA polymerase I stability. Richardson LA, et al. Cell Rep, 2012 Aug 30. PMID 22902402, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables chitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitin binding IEA
Inferred from Electronic Annotation
more info
  
enables chitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables endochitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables exochitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chitin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in polysaccharide catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
involved_in sporulation resulting in formation of a cellular spore IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
putative chitinase
NP_010659.1
  • Chitinase; contains both exochitinase and endochitinase activities in vitro with higher chitobiosidase activity; glycoside hydrolase GH18 family member with putative N-terminal transmembrane domain; functionally complements A. gossypii cts2 mutant sporulation defect

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1219413..1220948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180679.1 → NP_010659.1  TPA: putative chitinase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010659.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT02, Q06350
    UniProtKB/TrEMBL
    A0A8H8UNR7, A6ZYW9, C8Z5T2, N1P723
    Conserved Domains (1) summary
    COG3325
    Location:36 → 474
    ChiA; Chitinase, GH18 family [Carbohydrate transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06350.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous