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ADE8 phosphoribosylglycinamide formyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852017, updated on 11-Apr-2024

Summary

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Gene symbol
ADE8
Gene description
phosphoribosylglycinamide formyltransferase
Primary source
SGD:S000002816
Locus tag
YDR408C
See related
AllianceGenome:SGD:S000002816
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphoribosylglycinamide formyltransferase activity. Involved in 'de novo' IMP biosynthetic process and adenine biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1288215..1288859, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette multidrug transporter PDR15 Neighboring gene Trs120p Neighboring gene SUMO ligase SIZ1 Neighboring gene protein-S-isoprenylcysteine carboxyl O-methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The accumulation of glycinamide ribotide by ade3 and ade8 mutants of Saccharomyces cerevisiae. Woods RA, et al. Biochem Biophys Res Commun, 1973 Aug 6. PMID 4581491
  2. Gene conversion, unequal crossing-over and mispairing at a non-tandem duplication during meiosis of Saccharomyces cerevisiae. Maloney DH, et al. Curr Genet, 1987. PMID 3329573
  3. A DNA sequence conferring high postmeiotic segregation frequency to heterozygous deletions in Saccharomyces cerevisiae is related to sequences associated with eucaryotic recombination hotspots. White JH, et al. Mol Cell Biol, 1988 Mar. PMID 3285179, Free PMC Article
  4. Sequence of a Drosophila DNA segment that functions in Saccharomyces cerevisiae and its regulation by a yeast promoter. Henikoff S, et al. Nucleic Acids Res, 1983 Feb 11. PMID 6300768, Free PMC Article
  5. The Saccharomyces cerevisiae ADE5,7 protein is homologous to overlapping Drosophila melanogaster Gart polypeptides. Henikoff S. J Mol Biol, 1986 Aug 20. PMID 3097325

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylglycinamide formyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylglycinamide formyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylglycinamide formyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables phosphoribosylglycinamide formyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' IMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adenine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in purine-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
phosphoribosylglycinamide formyltransferase
NP_010696.3
  • Phosphoribosyl-glycinamide transformylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1288215..1288859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180716.3 → NP_010696.3  TPA: phosphoribosylglycinamide formyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010696.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT40, P04161
    UniProtKB/TrEMBL
    A0A8H8UNV2, A6ZZ07, B3LFP6, B5VGU0, C7GSB6, C8Z5X2, G2WBE6, N1P761
    Conserved Domains (1) summary
    pfam00551
    Location:2 → 205
    Formyl_trans_N; Formyl transferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04161.1

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