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KRE2 alpha-1,2-mannosyltransferase KRE2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852094, updated on 11-Apr-2024

Summary

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Gene symbol
KRE2
Gene description
alpha-1,2-mannosyltransferase KRE2
Primary source
SGD:S000002891
Locus tag
YDR483W
See related
AllianceGenome:SGD:S000002891
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MNT1
Summary
Enables alpha-1,2-mannosyltransferase activity. Involved in N-glycan processing; cell wall mannoprotein biosynthetic process; and protein O-linked glycosylation. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1421157..1422485)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene alkaline phosphatase PHO8 Neighboring gene U2-type spliceosomal complex subunit CWC21 Neighboring gene Vps52p Neighboring gene Vps72p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Base-modified GDP-mannose derivatives and their substrate activity towards a yeast mannosyltransferase. Collier A, et al. Carbohydr Res, 2017 Nov 27. PMID 29080432
  2. A theoretical study on the catalytic mechanism of the retaining α-1,2-mannosyltransferase Kre2p/Mnt1p: the impact of different metal ions on catalysis. Bobovská A, et al. Org Biomol Chem, 2014 Jun 28. PMID 24831692
  3. Structure of Kre2p/Mnt1p: a yeast alpha1,2-mannosyltransferase involved in mannoprotein biosynthesis. Lobsanov YD, et al. J Biol Chem, 2004 Apr 23. PMID 14752117
  4. Golgi localization and in vivo activity of a mammalian glycosyltransferase (human beta1,4-galactosyltransferase) in yeast. Schwientek T, et al. J Biol Chem, 1996 Feb 16. PMID 8631939
  5. Localization and targeting of the Saccharomyces cerevisiae Kre2p/Mnt1p alpha 1,2-mannosyltransferase to a medial-Golgi compartment. Lussier M, et al. J Cell Biol, 1995 Nov. PMID 7490293, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alpha-1,2-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,2-mannosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell wall mannoprotein biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell wall mannoprotein biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-1,2-mannosyltransferase KRE2
NP_010771.1
  • Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1421157..1422485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180791.1 → NP_010771.1  TPA: alpha-1,2-mannosyltransferase KRE2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010771.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTA6, P27809
    UniProtKB/TrEMBL
    A0A8H8UP14, B3LFI3, B5VH10, C7GKS2, C8Z641, N1P908
    Conserved Domains (1) summary
    COG5020
    Location:35 → 438
    KTR1; Mannosyltransferase [Carbohydrate transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27809.1

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