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GNP1 glutamine permease GNP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852121, updated on 25-Apr-2024

Summary

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Gene symbol
GNP1
Gene description
glutamine permease GNP1
Primary source
SGD:S000002916
Locus tag
YDR508C
See related
AllianceGenome:SGD:S000002916
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables L-proline transmembrane transporter activity. Involved in cellular sphingolipid homeostasis and serine import across plasma membrane. Located in several cellular components, including cellular bud neck; endoplasmic reticulum; and mitochondrion. Human ortholog(s) of this gene implicated in cystinuria; lysinuric protein intolerance; and retinitis pigmentosa 68. Orthologous to several human genes including SLC7A1 (solute carrier family 7 member 1); SLC7A14 (solute carrier family 7 member 14); and SLC7A2 (solute carrier family 7 member 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1466453..1468444, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene protein kinase GIN4 Neighboring gene SUMO family protein SMT3 Neighboring gene Sdh7p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GNP1, the high-affinity glutamine permease of S. cerevisiae. Zhu X, et al. Curr Genet, 1996 Jul 31. PMID 8660458
  2. Genome-wide expression analysis of genes affected by amino acid sensor Ssy1p in Saccharomyces cerevisiae. Kodama Y, et al. Curr Genet, 2002 May. PMID 12073087
  3. Amino acid residues important for substrate specificity of the amino acid permeases Can1p and Gnp1p in Saccharomyces cerevisiae. Regenberg B, et al. Yeast, 2001 Nov. PMID 11746604
  4. Four permeases import proline and the toxic proline analogue azetidine-2-carboxylate into yeast. Andréasson C, et al. Yeast, 2004 Feb. PMID 14968425
  5. Effect of the deubiquitination enzyme gene UBP6 on the stress-responsive transcription factor Msn2-mediated control of the amino acid permease Gnp1 in yeast. Mat Nanyan NSB, et al. J Biosci Bioeng, 2020 Apr. PMID 31640922

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Uptake of exogenous serine is important to maintain sphingolipid homeostasis in Saccharomyces cerevisiae.
    Title: Uptake of exogenous serine is important to maintain sphingolipid homeostasis in Saccharomyces cerevisiae.
  2. An excess level of Msn2 impairs endocytic degradation of Gnp1 through dysfunction of Ubp6 and other deubiquitinating enzymes.
    Title: Effect of the deubiquitination enzyme gene UBP6 on the stress-responsive transcription factor Msn2-mediated control of the amino acid permease Gnp1 in yeast.
  3. Using in silico analyses and mutational studies we found that the C-terminal sequences of Gap1, Bap2, Hip1, Tat1, Tat2, Mmp1, Sam3, Agp1, and Gnp1 are about 50 residues long, associate with the Plasma Membrane , and have features that discriminate them from the termini of organellar amino acid transporters
    Title: A Plasma Membrane Association Module in Yeast Amino Acid Transporters.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables L-proline transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular sphingolipid homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organic substance transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proline transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in serine import across plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in serine import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in cellular bud neck HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutamine permease GNP1
NP_010796.1
  • Broad specificity amino acid permease; high-affinity glutamine permease; major serine permease with minor contributions from paralog Agp1p; role in serine uptake impacts cellular sphingolipid homeostasis; also transports Leu, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1466453..1468444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180816.1 → NP_010796.1  TPA: glutamine permease GNP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010796.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTD0, P48813
    UniProtKB/TrEMBL
    A0A8H8UP37, G2WBN6, N1P7H3
    Conserved Domains (1) summary
    TIGR00913
    Location:146 → 626
    2A0310; amino acid permease (yeast)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48813.2

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