U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

QCR7 ubiquinol--cytochrome-c reductase subunit 7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852142, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Gene symbol
QCR7
Gene description
ubiquinol--cytochrome-c reductase subunit 7
Primary source
SGD:S000002937
Locus tag
YDR529C
See related
AllianceGenome:SGD:S000002937
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
COR4; CRO1; UCR7
Summary
Contributes to ubiquinol-cytochrome-c reductase activity. Involved in mitochondrial electron transport, ubiquinol to cytochrome c and mitochondrial respiratory chain complex III assembly. Located in mitochondrion. Part of mitochondrial respiratory chain complex III. Human ortholog(s) of this gene implicated in inherited metabolic disorder and mitochondrial complex III deficiency nuclear type 3. Orthologous to human UQCRB (ubiquinol-cytochrome c reductase binding protein). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1496165..1496548, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Hlr1p Neighboring gene bifunctional AP-4-A phosphorylase/ADP sulfurylase Neighboring gene pantothenate kinase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The functional role of conserved acidic residues of the Qcr7 protein of the cytochrome bc(1) complex in Saccharomyces cerevisiae. Lee SY, et al. Arch Biochem Biophys, 2001 Sep 15. PMID 11556807
  2. The N terminus of the Qcr7 protein of the cytochrome bc1 complex is not essential for import into mitochondria in Saccharomyces cerevisiae but is essential for assembly of the complex. Malaney S, et al. J Biol Chem, 1997 Jul 11. PMID 9211895
  3. The C-terminus of the 14-kDa subunit of ubiquinol-cytochrome-c oxidoreductase of the yeast Saccharomyces cerevisiae is involved in the assembly of a functional enzyme. Hemrika W, et al. Eur J Biochem, 1994 Mar 1. PMID 8125116
  4. Identification of additional homologues of subunits VII and VIII of the ubiquinol-cytochrome c oxidoreductase enables definition of consensus sequences. Boumans H, et al. FEBS Lett, 1995 Jul 10. PMID 7615060
  5. The biosynthesis of the ubiquinol-cytochrome c reductase complex in yeast. DNA sequence analysis of the nuclear gene coding for the 14-kDa subunit. De Haan M, et al. Eur J Biochem, 1984 Jan 2. PMID 6319130

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Process Evidence Code Pubs
involved_in aerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial respiratory chain complex III assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial respiratory chain complex III IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex III IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial respiratory chain complex III IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in respirasome IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ubiquinol--cytochrome-c reductase subunit 7
NP_010818.1
  • Subunit 7 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1496165..1496548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180837.1 → NP_010818.1  TPA: ubiquinol--cytochrome-c reductase subunit 7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010818.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTF0, P00128
    UniProtKB/TrEMBL
    A0A6A5Q2H4, A6ZZB6, B3LFE2, C7GKW0, C8Z689, G2WBQ6, N1P5Y3
    Conserved Domains (1) summary
    pfam02271
    Location:19 → 118
    UCR_14kD; Ubiquinol-cytochrome C reductase complex 14kD subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
6HU9_G.1
6HU9_R.1
6T0B_G.1
6T0B_R.1
6T15_G.1
6T15_R.1
P00128.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous