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ILS1 isoleucine--tRNA ligase ILS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852202, updated on 5-May-2024

Summary

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Gene symbol
ILS1
Gene description
isoleucine--tRNA ligase ILS1
Primary source
SGD:S000000172
Locus tag
YBL076C
See related
AllianceGenome:SGD:S000000172
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables isoleucine-tRNA ligase activity. Involved in isoleucyl-tRNA aminoacylation. Located in cytosol. Orthologous to human IARS1 (isoleucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (81043..84261, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Nup170p Neighboring gene ubiquitin-like protein ATG8 Neighboring gene Hsp70 family ATPase SSA3 Neighboring gene U5 snRNP complex subunit AAR2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A. Miyamoto Y, et al. J Biol Chem, 2002 Aug 9. PMID 12050165
  2. Molecular mode of action of the antifungal beta-amino acid BAY 10-8888. Ziegelbauer K, et al. Antimicrob Agents Chemother, 1998 Sep. PMID 9736535, Free PMC Article
  3. Aminoacyl-tRNA synthetase complex in Saccharomyces cerevisiae. Harris CL, et al. Biochem J, 1995 Jul 1. PMID 7619074, Free PMC Article
  4. Structure of the yeast isoleucyl-tRNA synthetase gene (ILS1). DNA-sequence, amino-acid sequence of proteolytic peptides of the enzyme and comparison of the structure to those of other known aminoacyl-tRNA synthetases. Englisch U, et al. Biol Chem Hoppe Seyler, 1987 Aug. PMID 3311074
  5. Isolation and complete sequence of the yeast isoleucyl-tRNA synthetase gene (ILS1). Martindale DW, et al. Curr Genet, 1989 Feb. PMID 2663194

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA editing activity IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables isoleucine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isoleucine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables isoleucine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
Inferred from Electronic Annotation
more info
  
involved_in isoleucyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isoleucyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in isoleucyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
isoleucine--tRNA ligase ILS1
NP_009477.1
  • Cytoplasmic isoleucine-tRNA synthetase; target of the G1-specific inhibitor reveromycin A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    81043..84261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178316.1 → NP_009477.1  TPA: isoleucine--tRNA ligase ILS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009477.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPS6, P09436
    UniProtKB/TrEMBL
    A0A6A5Q0L4, A6ZKM5, B3LNK9, B5VDR4, C7GK57, G2W8T5, N1PAU7
    Conserved Domains (1) summary
    PLN02882
    Location:8 → 1037
    PLN02882; aminoacyl-tRNA ligase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09436.1

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