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COR1 ubiquinol--cytochrome-c reductase subunit COR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852235, updated on 11-Apr-2024

Summary

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Gene symbol
COR1
Gene description
ubiquinol--cytochrome-c reductase subunit COR1
Primary source
SGD:S000000141
Locus tag
YBL045C
See related
AllianceGenome:SGD:S000000141
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
QCR1
Summary
Contributes to ubiquinol-cytochrome-c reductase activity. Involved in aerobic respiration. Located in mitochondrion. Part of mitochondrial respiratory chain complex III. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human UQCRC1 (ubiquinol-cytochrome c reductase core protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (134143..135516, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Ede1p Neighboring gene Psy4p Neighboring gene uncharacterized protein Neighboring gene Ecm13p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Assembly of the mitochondrial membrane system. Characterization of COR1, the structural gene for the 44-kilodalton core protein of yeast coenzyme QH2-cytochrome c reductase. Tzagoloff A, et al. J Biol Chem, 1986 Dec 25. PMID 3023384
  2. Structure and function of the mitochondrial bc1 complex. Properties of the complex in temperature-sensitive cor1 mutants. Gatti DL, et al. J Biol Chem, 1990 Dec 15. PMID 2174874
  3. Characterization of the yeast HEM2 gene and transcriptional regulation of COX5 and COR1 by heme. Myers AM, et al. J Biol Chem, 1987 Dec 15. PMID 2445751
  4. Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation. Hill S, et al. Free Radic Biol Med, 2012 Aug 15. PMID 22705367, Free PMC Article
  5. Core I protein of bovine ubiquinol-cytochrome-c reductase; an additional member of the mitochondrial-protein-processing family. Cloning of bovine core I and core II cDNAs and primary structure of the proteins. Gencic S, et al. Eur J Biochem, 1991 Jul 1. PMID 1712295

See all (127) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein processing involved in protein targeting to mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial respiratory chain complex III IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in respirasome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquinol--cytochrome-c reductase subunit COR1
NP_009508.1
  • Core subunit of the ubiquinol-cytochrome c reductase complex; the ubiquinol-cytochrome c reductase complex (bc1 complex) is a component of the mitochondrial inner membrane electron transport chain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    134143..135516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178285.1 → NP_009508.1  TPA: ubiquinol--cytochrome-c reductase subunit COR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009508.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPV3, P07256
    UniProtKB/TrEMBL
    A0A6A5Q3X1, A6ZKQ2, C8Z3Q3, G2W8W2, N1P7D3
    Conserved Domains (1) summary
    COG0612
    Location:25 → 445
    PqqL; Predicted Zn-dependent peptidase [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07256.1

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