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ETR1 enoyl-[acyl-carrier-protein] reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852314, updated on 11-Apr-2024

Summary

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Gene symbol
ETR1
Gene description
enoyl-[acyl-carrier-protein] reductase
Primary source
SGD:S000000230
Locus tag
YBR026C
See related
AllianceGenome:SGD:S000000230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MRF1; MRF1'
Summary
Enables enoyl-[acyl-carrier-protein] reductase activity. Involved in aerobic respiration and fatty acid biosynthetic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in dystonia. Orthologous to human MECR (mitochondrial trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (292877..294019, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene putative thioredoxin peroxidase SCO2 Neighboring gene Obg-like ATPase Neighboring gene uncharacterized protein Neighboring gene putative protein kinase YPK3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Function of heterologous Mycobacterium tuberculosis InhA, a type 2 fatty acid synthase enzyme involved in extending C20 fatty acids to C60-to-C90 mycolic acids, during de novo lipoic acid synthesis in Saccharomyces cerevisiae. Gurvitz A, et al. Appl Environ Microbiol, 2008 Aug. PMID 18552191, Free PMC Article
  2. Structure-function analysis of enoyl thioester reductase involved in mitochondrial maintenance. Airenne TT, et al. J Mol Biol, 2003 Mar 14. PMID 12614607
  3. Candida tropicalis Etr1p and Saccharomyces cerevisiae Ybr026p (Mrf1'p), 2-enoyl thioester reductases essential for mitochondrial respiratory competence. Torkko JM, et al. Mol Cell Biol, 2001 Sep. PMID 11509667, Free PMC Article
  4. A protein which binds preferentially to single-stranded core sequence of autonomously replicating sequence is essential for respiratory function in mitochondrial of Saccharomyces cerevisiae. Yamazoe M, et al. J Biol Chem, 1994 May 27. PMID 8195160
  5. ZAP1-mediated modulation of triacylglycerol levels in yeast by transcriptional control of mitochondrial fatty acid biosynthesis. Singh N, et al. Mol Microbiol, 2016 Apr. PMID 26711224

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adr1 influenced the transcription levels of ETR1, but it did not alter the abundance of Etr1 protein.
    Title: A novel circuit overrides Adr1p control during expression of Saccharomyces cerevisiae 2-trans-enoyl-ACP reductase Etr1p of mitochondrial type 2 fatty acid synthase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H) IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
enoyl-[acyl-carrier-protein] reductase
NP_009582.1
  • 2-enoyl thioester reductase; member of the medium chain dehydrogenase/reductase family; localized to mitochondria, where it has a probable role in fatty acid synthesis; human MECR functionally complements the respiratory growth defect of the null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    292877..294019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178374.1 → NP_009582.1  TPA: enoyl-[acyl-carrier-protein] reductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009582.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ28, P38071, Q6Q5P2
    UniProtKB/TrEMBL
    A0A8H4BT05, A6ZKX2, B3LNB7, C7GM26, C8Z420, G2W933
    Conserved Domains (1) summary
    cd08290
    Location:21 → 345
    ETR; 2-enoyl thioester reductase (ETR)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38071.3

Gene LinkOut

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