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CDS1 phosphatidate cytidylyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852317, updated on 4-Jan-2025

Summary

Official Symbol
CDS1
Official Full Name
phosphatidate cytidylyltransferase
Primary source
SGD:S000000233
Locus tag
YBR029C
See related
AllianceGenome:SGD:S000000233; FungiDB:YBR029C; VEuPathDB:YBR029C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CDG1
Summary
Enables phosphatidate cytidylyltransferase activity. Involved in CDP-diacylglycerol biosynthetic process; phosphatidylinositol metabolic process; and phosphatidylserine metabolic process. Located in Golgi to plasma membrane transport vesicle and endoplasmic reticulum. Used to study cancer. Orthologous to human CDS1 (CDP-diacylglycerol synthase 1) and CDS2 (CDP-diacylglycerol synthase 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See CDS1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (296369..297742, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene putative protein kinase YPK3 Neighboring gene protein-lysine N-methyltransferase Neighboring gene ribosomal 60S subunit protein L4A

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by SGD

Component Evidence Code Pubs
located_in Golgi to plasma membrane transport vesicle PubMed 
located_in cytoplasmic vesicle  
located_in endoplasmic reticulum PubMed 
located_in endoplasmic reticulum PubMed 
located_in endoplasmic reticulum  
is_active_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum membrane  
located_in membrane  
located_in transport vesicle  

General protein information

Preferred Names
phosphatidate cytidylyltransferase
NP_009585.1
  • Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids; human homolog CDS1 can complement yeast cds1 null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    296369..297742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178377.1NP_009585.1  TPA: phosphatidate cytidylyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009585.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ30, P38221
    UniProtKB/TrEMBL
    A6ZKX4, B3LNB5, B5VDZ7, C7GM24, C8Z423, G2W935, N1P886
    Conserved Domains (1) summary
    cl21502
    Location:96420
    CTP_transf_1; Cytidylyltransferase family
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