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CDS1 phosphatidate cytidylyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852317, updated on 11-Apr-2024

Summary

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Gene symbol
CDS1
Gene description
phosphatidate cytidylyltransferase
Primary source
SGD:S000000233
Locus tag
YBR029C
See related
AllianceGenome:SGD:S000000233
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CDG1
Summary
Enables phosphatidate cytidylyltransferase activity. Involved in CDP-diacylglycerol biosynthetic process; phosphatidylinositol metabolic process; and phosphatidylserine metabolic process. Located in Golgi to plasma membrane transport vesicle and endoplasmic reticulum. Used to study cancer. Orthologous to human CDS1 (CDP-diacylglycerol synthase 1) and CDS2 (CDP-diacylglycerol synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (296369..297742, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene putative protein kinase YPK3 Neighboring gene protein-lysine N-methyltransferase Neighboring gene ribosomal 60S subunit protein L4A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The CDS1 gene encoding CDP-diacylglycerol synthase in Saccharomyces cerevisiae is essential for cell growth. Shen H, et al. J Biol Chem, 1996 Jan 12. PMID 8557688
  2. Saccharomyces cerevisiae mutant with a partial defect in the synthesis of CDP-diacylglycerol and altered regulation of phospholipid biosynthesis. Klig LS, et al. J Bacteriol, 1988 Apr. PMID 2832385, Free PMC Article
  3. Purification and characterization of CDP-diacylglycerol synthase from Saccharomyces cerevisiae. Kelley MJ, et al. J Biol Chem, 1987 Oct 25. PMID 2822695
  4. Enzymes of phosphoinositide synthesis in secretory vesicles destined for the plasma membrane in Saccharomyces cerevisiae. Kinney AJ, et al. J Bacteriol, 1990 Jul. PMID 2163397, Free PMC Article
  5. Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA. Weeks R, et al. DNA Cell Biol, 1997 Mar. PMID 9115637

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidate cytidylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidate cytidylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in CDP-diacylglycerol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylserine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi to plasma membrane transport vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in transport vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidate cytidylyltransferase
NP_009585.1
  • Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids; human homolog CDS1 can complement yeast cds1 null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    296369..297742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178377.1 → NP_009585.1  TPA: phosphatidate cytidylyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009585.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ30, P38221
    UniProtKB/TrEMBL
    A0A6A5Q482, A6ZKX4, B3LNB5, B5VDZ7, C7GM24, C8Z423, G2W935, N1P886
    Conserved Domains (1) summary
    cl21502
    Location:96 → 420
    CTP_transf_1; Cytidylyltransferase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38221.1

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