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TSC3 Tsc3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852350, updated on 13-Apr-2024

Summary

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Gene symbol
TSC3
Gene description
Tsc3p
Primary source
SGD:S000007521
Locus tag
YBR058C-A
See related
AllianceGenome:SGD:S000007521
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables enzyme activator activity. Involved in 3-keto-sphinganine metabolic process and positive regulation of sphingolipid biosynthetic process. Located in endoplasmic reticulum. Part of SPOTS complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (356324..356566, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Mum2p Neighboring gene ubiquitin-specific protease UBP14 Neighboring gene serine/threonine protein kinase AKL1 Neighboring gene origin recognition complex subunit 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations in the Lcb2p subunit of serine palmitoyltransferase eliminate the requirement for the TSC3 gene in Saccharomyces cerevisiae. Monaghan E, et al. Yeast, 2002 Jun 15. PMID 12185836
  2. Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway. Ren J, et al. J Lipid Res, 2018 Nov. PMID 30154231, Free PMC Article
  3. Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity. Gable K, et al. J Biol Chem, 2000 Mar 17. PMID 10713067
  4. Iron, glucose and intrinsic factors alter sphingolipid composition as yeast cells enter stationary phase. Lester RL, et al. Biochim Biophys Acta, 2013 Apr. PMID 23286903, Free PMC Article
  5. Multicopy suppressor analysis of thermosensitive YIP1 alleles implicates GOT1 in transport from the ER. Lorente-Rodríguez A, et al. J Cell Sci, 2009 May 15. PMID 19383723, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables enzyme activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3-keto-sphinganine metabolic process IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in positive regulation of sphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SPOTS complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tsc3p
NP_116327.3
  • Protein that stimulates the activity of serine palmitoyltransferase; involved in sphingolipid biosynthesis; Lcb1p and Lcb2p are the two components of serine palmitoyltransferase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    356324..356566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184442.3 → NP_116327.3  TPA: Tsc3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116327.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ58, Q3E790
    UniProtKB/TrEMBL
    A0A6A5Q613, A6ZL03, B3LN90, C7GQH4, D3UEF6, G2W964
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3E790.1

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