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PHO3 acid phosphatase PHO3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852389, updated on 7-Apr-2024

Summary

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Gene symbol
PHO3
Gene description
acid phosphatase PHO3
Primary source
SGD:S000000296
Locus tag
YBR092C
See related
AllianceGenome:SGD:S000000296
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables acid phosphatase activity. Involved in phosphate-containing compound metabolic process and thiamine-containing compound metabolic process. Located in cell wall-bounded periplasmic space. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia and thyroid gland papillary carcinoma. Orthologous to human MINPP1 (multiple inositol-polyphosphate phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (427698..429101, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene high-mobility group nucleosome-binding protein Neighboring gene Tim12p Neighboring gene acid phosphatase PHO5 Neighboring gene putative tubulin tyrosine ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning, expression and evaluation of phosphohydrolases for phytate-degrading activity. Moore E, et al. J Ind Microbiol, 1995 May. PMID 7612216
  2. Two yeast acid phosphatase structural genes are the result of a tandem duplication and show different degrees of homology in their promoter and coding sequences. Meyhack B, et al. EMBO J, 1982. PMID 6329697, Free PMC Article
  3. Acid phosphatase polypeptides in Saccharomyces cerevisiae are encoded by a differentially regulated multigene family. Rogers DT, et al. Proc Natl Acad Sci U S A, 1982 Apr. PMID 6212932, Free PMC Article
  4. Structural analysis of the two tandemly repeated acid phosphatase genes in yeast. Bajwa W, et al. Nucleic Acids Res, 1984 Oct 25. PMID 6093051, Free PMC Article
  5. Identity of soluble thiamin-binding protein with thiamin-repressible acid phosphatase in Saccharomyces cerevisiae. Nosaka K, et al. Biochim Biophys Acta, 1988 Oct 13. PMID 3048416

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effect of Deletions of the Genes Encoding Pho3p and Bgl2p on Polyphosphate Level, Stress Adaptation, and Attachments of These Proteins to Saccharomyces cerevisiae Cell Wall.
    Title: Effect of Deletions of the Genes Encoding Pho3p and Bgl2p on Polyphosphate Level, Stress Adaptation, and Attachments of These Proteins to Saccharomyces cerevisiae Cell Wall.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acid phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables acid phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphate-containing compound metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in thiamine-containing compound metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell wall-bounded periplasmic space IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
is_active_in fungal-type cell wall IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
acid phosphatase PHO3
NP_009650.1
  • Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    427698..429101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178440.1 → NP_009650.1  TPA: acid phosphatase PHO3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009650.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ93, P24031
    UniProtKB/TrEMBL
    A0A8H4BUB0, D3UEI7
    Conserved Domains (1) summary
    pfam00328
    Location:65 → 399
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24031.2

Gene LinkOut

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