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LYS2 L-aminoadipate-semialdehyde dehydrogenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852412, updated on 13-Apr-2024

Summary

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Gene symbol
LYS2
Gene description
L-aminoadipate-semialdehyde dehydrogenase
Primary source
SGD:S000000319
Locus tag
YBR115C
See related
AllianceGenome:SGD:S000000319
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables L-aminoadipate-semialdehyde dehydrogenase activity. Involved in lysine biosynthetic process via aminoadipic acid. Orthologous to human AASDH (aminoadipate-semialdehyde dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See LYS2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (469748..473926, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene transcription regulator CYC8 Neighboring gene DNA repair protein RAD16 Neighboring gene transketolase TKL2 Neighboring gene translation elongation factor EF-1 alpha

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning, sequencing and characterization of the alpha-aminoadipate reductase gene (LYS2) from Saccharomycopsis fibuligera. Yan H, et al. Yeast, 2007 Mar. PMID 17351909
  2. [Frameshift suppression through inactivation of translation termination in yeast Saccharomyces cerevisiae: significance of the local context]. Riabnikova NA, et al. Genetika, 2004 Jul. PMID 15458198
  3. Identification of a distinctive mutation spectrum associated with high levels of transcription in yeast. Lippert MJ, et al. Mol Cell Biol, 2004 Jun. PMID 15143174, Free PMC Article
  4. Identification of the cloned S. cerevisiae LYS2 gene by an integrative transformation approach. Eibel H, et al. Mol Gen Genet, 1983. PMID 6350829
  5. Lysine biosynthesis in Saccharomyces. Conversion of -aminoadipate into -aminoadipic -semialdehyde. Sinha AK, et al. Biochem J, 1971 Dec. PMID 4401608, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lys2 interaction with FLO8, STE11, SPT6 and RNA Polymerase II
    Title: Relationships Between RNA Polymerase II Activity and Spt Elongation Factors to Spt- Phenotype and Growth in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables L-aminoadipate-semialdehyde dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-aminoadipate-semialdehyde dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-aminoadipate-semialdehyde dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphopantetheine binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lysine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lysine biosynthetic process via aminoadipic acid IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lysine biosynthetic process via aminoadipic acid IEA
Inferred from Electronic Annotation
more info
  
involved_in lysine biosynthetic process via aminoadipic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
L-aminoadipate-semialdehyde dehydrogenase
NP_009673.1
  • Alpha aminoadipate reductase; catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    469748..473926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178463.1 → NP_009673.1  TPA: L-aminoadipate-semialdehyde dehydrogenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009673.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQB4, P07702
    UniProtKB/TrEMBL
    A0A8H4F7X1, B5VE77, N1P6N2
    Conserved Domains (1) summary
    TIGR03443
    Location:7 → 1379
    alpha_am_amid; L-aminoadipate-semialdehyde dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07702.2

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