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TYR1 prephenate dehydrogenase (NADP(+)) [ Saccharomyces cerevisiae S288C ]

Gene ID: 852464, updated on 25-Apr-2024

Summary

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Gene symbol
TYR1
Gene description
prephenate dehydrogenase (NADP(+))
Primary source
SGD:S000000370
Locus tag
YBR166C
See related
AllianceGenome:SGD:S000000370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables prephenate dehydrogenase (NAD+) activity. Involved in tyrosine biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (569842..571200, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Arf family GTPase ARL1 Neighboring gene Ubs1p Neighboring gene ribonuclease P/MRP protein subunit POP7 Neighboring gene Pex32p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biochemical characterization of TyrA dehydrogenases from Saccharomyces cerevisiae (Ascomycota) and Pleurotus ostreatus (Basidiomycota). Lopez-Nieves S, et al. Arch Biochem Biophys, 2019 Apr 15. PMID 30771296
  2. Characterization of the prephenate dehydrogenase-encoding gene, TYR1, from Saccharomyces cerevisiae. Mannhaupt G, et al. Gene, 1989 Dec 28. PMID 2697638
  3. Novel wine yeast with ARO4 and TYR1 mutations that overproduce 'floral' aroma compounds 2-phenylethanol and 2-phenylethyl acetate. Cordente AG, et al. Appl Microbiol Biotechnol, 2018 Jul. PMID 29744630
  4. A Novel Assay Reveals a Maturation Process during Ascospore Wall Formation. Zhang K, et al. J Fungi (Basel), 2017 Oct 2. PMID 29371570, Free PMC Article
  5. Metabolic engineering of a tyrosine-overproducing yeast platform using targeted metabolomics. Gold ND, et al. Microb Cell Fact, 2015 May 28. PMID 26016674, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables prephenate dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables prephenate dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables prephenate dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables prephenate dehydrogenase (NAD+) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables prephenate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tyrosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tyrosine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tyrosine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tyrosine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 

General protein information

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Preferred Names
prephenate dehydrogenase (NADP(+))
NP_009725.1
  • Prephenate dehydrogenase involved in tyrosine biosynthesis; expression is dependent on phenylalanine levels

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    569842..571200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178514.1 → NP_009725.1  TPA: prephenate dehydrogenase (NADP(+)) [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009725.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQG2, P20049
    UniProtKB/TrEMBL
    A0A8H4BU32, G2W9G9, N1P8K9
    Conserved Domains (1) summary
    COG0287
    Location:11 → 288
    TyrA; Prephenate dehydrogenase [Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20049.2

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