U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RIM2 Rim2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852491, updated on 17-May-2024

Summary

Go to the top of the page Help
Gene symbol
RIM2
Gene description
Rim2p
Primary source
FungiDB:YBR192W
Locus tag
YBR192W
See related
SGD:S000000396; AllianceGenome:SGD:S000000396
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PYT1
Summary
Enables pyrimidine nucleotide transmembrane transporter activity. Involved in several processes, including metal ion transport; mitochondrial genome maintenance; and pyrimidine nucleotide transport. Located in mitochondrion. Orthologous to several human genes including SLC25A36 (solute carrier family 25 member 36). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See RIM2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (607652..608785)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S9B Neighboring gene ribosomal 60S subunit protein L21A Neighboring gene Med8p Neighboring gene Aim4p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Splitting the functions of Rim2, a mitochondrial iron/pyrimidine carrier. Knight SAB, et al. Mitochondrion, 2019 Jul. PMID 30660752, Free PMC Article
  2. Identification of a mitochondrial transporter for pyrimidine nucleotides in Saccharomyces cerevisiae: bacterial expression, reconstitution and functional characterization. Marobbio CM, et al. Biochem J, 2006 Jan 15. PMID 16194150, Free PMC Article
  3. The mitochondrial carrier Rim2 co-imports pyrimidine nucleotides and iron. Froschauer EM, et al. Biochem J, 2013 Oct 1. PMID 23800229
  4. Overexpression of a novel member of the mitochondrial carrier family rescues defects in both DNA and RNA metabolism in yeast mitochondria. Van Dyck E, et al. Mol Gen Genet, 1995 Feb 20. PMID 7891656
  5. Rim2, a pyrimidine nucleotide exchanger, is needed for iron utilization in mitochondria. Yoon H, et al. Biochem J, 2011 Nov 15. PMID 21777202, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mitochondrial iron transport and pyrimidine transport by Rim2 occur separately and independently. Rim2 could be a bifunctional carrier protein.
    Title: Splitting the functions of Rim2, a mitochondrial iron/pyrimidine carrier.
  2. In the absence of the main iron transporters Mrs3 and Mrs4, Rim2 carrier can supply the mitochondrial matrix with iron in a pyrimidine-nucleotide-dependent fashion.
    Title: The mitochondrial carrier Rim2 co-imports pyrimidine nucleotides and iron.
  3. Rim2 is a pyrimidine exchanger with an additional unique function in promoting mitochondrial iron utilization
    Title: Rim2, a pyrimidine nucleotide exchanger, is needed for iron utilization in mitochondria.
  4. Rim2p has been identified as a yeast mitochondrial pyrimidine nucleotide transporter
    Title: Identification of a mitochondrial transporter for pyrimidine nucleotides in Saccharomyces cerevisiae: bacterial expression, reconstitution and functional characterization.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables pyrimidine nucleotide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyrimidine nucleotide transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyrimidine nucleotide transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in metal ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial genome maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial genome maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organic substance transport IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleotide import into mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyrimidine nucleotide transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Rim2p
NP_009751.1
  • Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    607652..608785
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178540.1 → NP_009751.1  TPA: Rim2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009751.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQI6, P38127
    UniProtKB/TrEMBL
    A0A6A5Q5E8, A6ZLD2, B3LMX0, C7GKF1, D3UET6, G2W9J3, N1P8M6
    Conserved Domains (2) summary
    PTZ00169
    Location:72 → 264
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:294 → 377
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38127.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous