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KTR4 putative mannosyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852498, updated on 13-Apr-2024

Summary

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Gene symbol
KTR4
Gene description
putative mannosyltransferase
Primary source
SGD:S000000403
Locus tag
YBR199W
See related
AllianceGenome:SGD:S000000403
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mannosyltransferase activity. Predicted to be involved in glycoprotein biosynthetic process and mannosylation. Located in fungal-type vacuole. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (618909..620303)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene chromatin modification protein Neighboring gene phosphatidylinositol-3-phosphate-binding protein BEM1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of the Glycosyltransferase Ktr4p from Saccharomyces cerevisiae. Possner DD, et al. PLoS One, 2015. PMID 26296208, Free PMC Article
  2. Nucleotide sequence analysis of an 11.7 kb fragment of yeast chromosome II including BEM1, a new gene of the WD-40 repeat family and a new member of the KRE2/MNT1 family. Mallet L, et al. Yeast, 1994 Jun. PMID 7975899
  3. Saccharomyces cerevisiae KTR4, KTR5 and KTR7 encode mannosyltransferases differentially involved in the N- and O-linked glycosylation pathways. Hernández NV, et al. Res Microbiol, 2017 Oct. PMID 28774774
  4. Completion of the Saccharomyces cerevisiae genome sequence allows identification of KTR5, KTR6 and KTR7 and definition of the nine-membered KRE2/MNT1 mannosyltransferase gene family in this organism. Lussier M, et al. Yeast, 1997 Mar 15. PMID 9090056
  5. Functional characterization of the YUR1, KTR1, and KTR2 genes as members of the yeast KRE2/MNT1 mannosyltransferase gene family. Lussier M, et al. J Biol Chem, 1996 May 3. PMID 8631921

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KTR4, KTR5 and KTR7 have a redundant activity in the S. cerevisiae N-linked glycosylation pathway, but KTR4 plays a major role in O-linked glycan synthesis.
    Title: Saccharomyces cerevisiae KTR4, KTR5 and KTR7 encode mannosyltransferases differentially involved in the N- and O-linked glycosylation pathways.
  2. The crystal structure of the glycosyltransferase Ktr4p from Saccharomyces cerevisiae has been solved.
    Title: Structure of the Glycosyltransferase Ktr4p from Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alpha-1,2-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell wall mannoprotein biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative mannosyltransferase
NP_009758.3
  • Glycosyltransferase involved in protein glycosylation; transfers GDP-mannose to methyl-alpha-mannoside in vitro; member of the KRE2/MNT1 mannosyltransferase family of type II membrane proteins with a short cytoplasmic N-terminus, a membrane-spanning region and a highly conserved catalytic lumenal domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    618909..620303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178547.3 → NP_009758.3  TPA: putative mannosyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009758.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQJ5, P38131, P89506
    UniProtKB/TrEMBL
    A0A8H4BU50, C7GKG0, G2W9K2, N1P8E8
    Conserved Domains (1) summary
    COG5020
    Location:10 → 464
    KTR1; Mannosyltransferase [Carbohydrate transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38131.1

Gene LinkOut

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