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KTR3 mannosyltransferase KTR3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852504, updated on 11-Apr-2024

Summary

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Gene symbol
KTR3
Gene description
mannosyltransferase KTR3
Primary source
SGD:S000000409
Locus tag
YBR205W
See related
AllianceGenome:SGD:S000000409
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mannosyltransferase activity. Involved in N-glycan processing and protein O-linked glycosylation. Located in fungal-type vacuole membrane and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (633622..634836)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Cos111p Neighboring gene triacylglycerol lipase Neighboring gene Fth1p Neighboring gene bifunctional urea carboxylase/allophanate hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Svp26 facilitates ER exit of mannosyltransferases Mnt2 and Mnt3 in Saccharomyces cerevisiae. Tanabe Y, et al. J Gen Appl Microbiol, 2019 Sep 14. PMID 30700649
  2. Molecular dissection of Erv26p identifies separable cargo binding and coat protein sorting activities. Bue CA, et al. J Biol Chem, 2009 Sep 4. PMID 19574229, Free PMC Article
  3. The Ktr1p, Ktr3p, and Kre2p/Mnt1p mannosyltransferases participate in the elaboration of yeast O- and N-linked carbohydrate chains. Lussier M, et al. J Biol Chem, 1997 Jun 13. PMID 9182588
  4. Functional characterization of the YUR1, KTR1, and KTR2 genes as members of the yeast KRE2/MNT1 mannosyltransferase gene family. Lussier M, et al. J Biol Chem, 1996 May 3. PMID 8631921
  5. Distinct adaptor proteins assist exit of Kre2-family proteins from the yeast ER. Noda Y, et al. Biol Open, 2014 Mar 15. PMID 24585773, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alpha-1,2-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-glycan processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell wall mannoprotein biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
mannosyltransferase KTR3
NP_009764.3
  • Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    633622..634836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178553.3 → NP_009764.3  TPA: mannosyltransferase KTR3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009764.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQK3, E9P931, P38130
    UniProtKB/TrEMBL
    A0A6A5Q0A5, A6ZLE7, B3LMV3, B5VEF7, C7GKG8, D3UEV2, G2W9L0
    Conserved Domains (1) summary
    COG5020
    Location:1 → 404
    KTR1; Mannosyltransferase [Carbohydrate transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38130.1

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