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YBR284W metallo-dependent hydrolase superfamily protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 852587, updated on 11-Apr-2024

Summary

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Gene symbol
YBR284W
Gene description
metallo-dependent hydrolase superfamily protein
Primary source
SGD:S000000488
Locus tag
YBR284W
See related
AllianceGenome:SGD:S000000488
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 63 and pontocerebellar hypoplasia type 9. Orthologous to human AMPD1 (adenosine monophosphate deaminase 1); AMPD2 (adenosine monophosphate deaminase 2); and AMPD3 (adenosine monophosphate deaminase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YBR284W in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (771239..773632)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL27 Neighboring gene Ssh1p Neighboring gene uncharacterized protein Neighboring gene aminopeptidase Y

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The sequence of a 32,420 bp segment located on the right arm of chromosome II from Saccharomyces cerevisiae. Holmstrøm K, et al. Yeast, 1994 Apr. PMID 8091861
  2. Phenotypic consequences of purine nucleotide imbalance in Saccharomyces cerevisiae. Saint-Marc C, et al. Genetics, 2009 Oct. PMID 19635936, Free PMC Article
  3. Generation of null alleles for the functional analysis of six genes from the right arm of Saccharomyces cerevisiae chromosome II. Dueñas E, et al. Yeast, 1999 May. PMID 10341424
  4. Insights into TOR function and rapamycin response: chemical genomic profiling by using a high-density cell array method. Xie MW, et al. Proc Natl Acad Sci U S A, 2005 May 17. PMID 15883373, Free PMC Article
  5. Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. Gatbonton T, et al. PLoS Genet, 2006 Mar. PMID 16552446, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
metallo-dependent hydrolase superfamily protein
NP_009843.3
  • Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    771239..773632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178632.3 → NP_009843.3  TPA: metallo-dependent hydrolase superfamily protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009843.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQS9, P38150
    UniProtKB/TrEMBL
    A0A8H4BUN1, G2W9T7, N1P790
    Conserved Domains (1) summary
    COG1816
    Location:341 → 748
    Add; Adenosine deaminase [Nucleotide transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38150.1

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