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TPN1 Tpn1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852689, updated on 13-Apr-2024

Summary

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Gene symbol
TPN1
Gene description
Tpn1p
Primary source
SGD:S000003154
Locus tag
YGL186C
See related
AllianceGenome:SGD:S000003154
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables vitamin transmembrane transporter activity. Involved in vitamin transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (151037..152776, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene cytochrome c oxidase subunit IV Neighboring gene putative hydroxyacid dehydrogenase Neighboring gene cystathionine beta-lyase STR3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Amiloride uptake and toxicity in fission yeast are caused by the pyridoxine transporter encoded by bsu1+ (car1+). Stolz J, et al. Eukaryot Cell, 2005 Feb. PMID 15701794, Free PMC Article
  2. Tpn1p, the plasma membrane vitamin B6 transporter of Saccharomyces cerevisiae. Stolz J, et al. J Biol Chem, 2003 May 23. PMID 12649274
  3. Plasticity of an ultrafast interaction between nucleoporins and nuclear transport receptors. Milles S, et al. Cell, 2015 Oct 22. PMID 26456112, Free PMC Article
  4. Various cytosine/adenine permease homologues are involved in the toxicity of 5-fluorocytosine in Saccharomyces cerevisiae. Paluszynski JP, et al. Yeast, 2006 Jul 15. PMID 16845689
  5. A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions. Kanellis P, et al. PLoS Genet, 2007 Aug. PMID 17696614, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables vitamin transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vitamin transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vitamin transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Tpn1p
NP_011329.1
  • Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    151037..152776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181051.1 → NP_011329.1  TPA: Tpn1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011329.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTW8, P53099, Q874L4
    UniProtKB/TrEMBL
    A0A8H4C1S6, A6ZU02, B5VIE5, C7GX08, N1P4A2
    Conserved Domains (1) summary
    TIGR00800
    Location:70 → 510
    ncs1; NCS1 nucleoside transporter family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53099.1

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